Graham Taylor

2024

Bioengineered small extracellular vesicles deliver multiple SARS‐CoV‐2 antigenic fragments and drive a broad immunological response

Jackson, H. K., Long, H. M., Yam‐Puc, J. C., Palmulli, R., Haigh, T. A., Gerber, P. P., Lee, J. S., Matheson, N. J., Young, L., Trowsdale, J., Lo, M., Taylor, G. S., Thaventhiran, J. E. & Edgar, J. R., 9 Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, e12412.

Research output: Contribution to journal › Article › peer-review

Open Access

File

30 Downloads (Pure)

Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling

Syrimi, E., Khan, N., Murray, P., Willcox, C., Haigh, T., Willcox, B., Masand, N., Bowen, C., Dimakou, D. B., Zuo, J., Barone, S. M., Irish, J. M., Kearns, P. & Taylor, G. S., 28 Aug 2024, (E-pub ahead of print) In: iScience. 110837.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Downloads (Pure)

Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children

Zhang, Z., Kean, I. R. L., Dratva, L. M., Clark, J. A., Syrimi, E., Khan, N., Daubney, E., White, D., O’Neill, L., Chisholm, C., Payne, C., Benkenstein, S., Kupiec, K., Galassini, R., Wright, V., Winmill, H., Robbins, C., Brown, K., Ramnarayan, P., Scholefield, B., & 8 othersPeters, M., Klein, N., Montgomery, H., Meyer, K. B., Teichmann, S. A., Bryant, C., Taylor, G. & Pathan, N., 18 May 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 4227.

Research output: Contribution to journal › Article › peer-review

Open Access

File

22 Downloads (Pure)

Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis

Thomas, O. G., Haigh, T. A., Croom-Carter, D., Leese, A., Van Wijck, Y., Douglas, M. R., Rickinson, A., Brooks, J. M. & Taylor, G. S., 6 Jun 2024, In: PLoS Pathogens. 20, 6, 27 p., e1012177.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Downloads (Pure)

2023

A proinflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies

Costigan, D., Fenn, J., Yen, S., Ilott, N., Bullers, S., Hale, J., Greenhalf, W., Conibear, E., Koycheva, A., Madon, K., Jahan, I., Huang, M., Badhan, A., Parker, E., Rosadas, C., Jones, K., McClure, M., Tedder, R., Taylor, G., Baillie, K. J., & 6 othersSemple, M. G., Openshaw, P. JM., Pearson, C., Johnson, J., Lalvani, A. & Thornton, E. E., Nov 2023, In: Mucosal immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping

Payne, K., Brooks, J., Batis, N., Khan, N., El-Asrag, M., Nankivell, P., Mehanna, H. & Taylor, G., 9 Nov 2023, In: British Journal of Cancer. 129, 10, p. 1590-1598 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

56 Downloads (Pure)

Mendelian randomisation identifies priority groups for prophylactic EBV vaccination

Muckian, M. D., Wilson, J. F., Taylor, G. S., Stagg, H. R. & Pirastu, N., 3 Feb 2023, In: BMC Infectious Diseases. 23, 1, 9 p., 65.

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Downloads (Pure)

Role of AI and digital pathology for colorectal immuno-oncology

Bilal, M., Nimir, M., Snead, D., Taylor, G. S. & Rajpoot, N., 26 Jan 2023, In: British Journal of Cancer. 128, 1, p. 3-11 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

24 Downloads (Pure)

2022

Characterising the epithelial-mesenchymal transition status of circulating tumour cells in head and neck squamous cell carcinoma

Payne, K., Brooks, J., Batis, N., Taylor, G., Nankivell, P. & Mehanna, H., 5 Aug 2022, In: Head & Neck. 44, 11, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

78 Downloads (Pure)

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Dowell, A. C., Butler, M. S., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R., Pearce, H., Verma, K., Logan, N., Tyson, G., Spalkova, E., Margielewska-Davies, S., Taylor, G. S., Syrimi, E., Baawuah, F., Beckmann, J., Okike, I. O., Ahmad, S., & 24 othersGarstang, J., Brent, A. J., Brent, B., Ireland, G., Aiano, F., Amin-Chowdhury, Z., Jones, S., Borrow, R., Linley, E., Wright, J., Azad, R., Waiblinger, D., Davis, C., Thomson, E. C., Palmarini, M., Willett, B. J., Barclay, W. S., Poh, J., Amirthalingam, G., Brown, K. E., Ramsay, M. E., Zuo, J., Moss, P. & Ladhani, S., Jan 2022, In: Nature Immunology. 23, 1, p. 40-49 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

60 Downloads (Pure)

LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity

Bombaci, G., Sarangdhar, M. A., Andina, N., Tardivel, A., Yu, E. C. W., Mackie, G. M., Pugh, M., Ozan, V. B., Banz, Y., Spinetti, T., Hirzel, C., Youd, E., Schefold, J. C., Taylor, G., Gazdhar, A., Bonadies, N., Angelillo-Scherrer, A., Schneider, P., Maslowski, K. M. & Allam, R., Jun 2022, In: Life Science Alliance. 5, 6, e202101226.

Research output: Contribution to journal › Article › peer-review

Open Access

File

121 Downloads (Pure)

Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

Pugh, M., Fennell, E., Leahy, C. I., Perry, T., Hargitai, B., Marton, T., Hunter, K., Halford, G., Yilmaz, H. O., Stamataki, Z., Reynolds, G., Hill, H. J., Willcox, B. E., Steven, N., Thornton, C. A., Dojcinov, S. D., Culhane, A., Murray, P. G. & Taylor, G. S., 14 Nov 2022, bioRxiv.

Research output: Working paper/Preprint › Preprint

Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4⁺ T cell recognition

Tye, E., Jinks, E., Haigh, T., Kaul, B., Patel, P., Parry, H., Newby, M., Crispin, M., Kaur, N., Moss, P., Drennan, S., Taylor, G. & Long, H., 1 Dec 2022, In: Nature Immunology. 23, p. 1726–1734 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

42 Downloads (Pure)

Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature

Khan, A., Reyat, J., Hill, H., Bourne, J., Colicchia, M., Newby, M. L., Allen, J. D., Crispin, M., Youd, E., Murray, P., Taylor, G., Stamataki, Z., Richter, A., Cunningham, A., Pugh, M. & Rayes, J., Nov 2022, In: Cardiovascular Research. 118, 15, p. 3085–3096 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

50 Downloads (Pure)

SARS-CoV-2 in the abdomen or pelvis: SAFE SURGERY study

Vimalachandran, D., Jones, R. P., Dickson, E., Seehra, J., Acheson, A., Griffiths, E. A., Kamarajah, S., Leung, E., Torrance, A., Ottensmeier, C., Beggs, A. D., Whiteside, E., Sanna, H., Bury, D., Youd, E., Leopold, G., Pugh, M., Sundar, S. & Taylor, G. S., 28 Sept 2022, (E-pub ahead of print) In: British Journal of Surgery.

Research output: Contribution to journal › Article › peer-review

Open Access

File

52 Downloads (Pure)

Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program

McMurray, J., von Borstel, A., Taher, T., Syrimi, E., Taylor, G., Sharif, M., Rossjohn, J., Remmerswaal, E., Bemelman, F., Vieira Braga, F. A., Chen, X., Teichmann, S. A., Mohammed, F., Berry, A., Lyke, K., Williamson, K., Stubbington, M., Davey, M., Willcox, C. & Willcox, B., 24 May 2022, In: Cell Reports. 39, 8, 22 p., 110858.

Research output: Contribution to journal › Article › peer-review

Open Access

File

91 Downloads (Pure)

2021

Children develop strong and sustained cross-reactive immune responses against Spike protein following SARS-CoV-2 infection, with enhanced recognition of variants of concern

Dowell, A., Butler, M. S., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R., Pearce, H., Verma, K., Logan, N., Tyson, G., Spalkova, E., Margielewska-Davies, S., Taylor, G., Syrimi, E., Baawuah, F., Beckmann, J., Okike, I., Ahmad, S., & 25 othersGarstang, J., Brent, A. J., Brent, B., Ireland, G., Aiano, F., Amin-Chowdhury, Z., Jones, S., Borrow, R., Linley, E., Wright, J., Azad, R., Waiblinger, D., Davis, C., Thomson, E., Palmarini, M., Willett, B. J., Barclay, W. S., Poh, J., Saliba, V., Amirthalingam, G., Brown, K. E., Ramsay, M. E., Zuo, J., Moss, P. & Ladhani, S., 28 Sept 2021, medRxiv.

Research output: Working paper/Preprint › Preprint

Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors

Dowell, A. C., Haigh, T. A., Ryan, G. B., Turner, J. E., Long, H. M. & Taylor, G. S., 9 Dec 2021, In: PLoS Pathogens. 17, 12, e1010137.

Research output: Contribution to journal › Article › peer-review

Open Access

File

49 Downloads (Pure)

Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

Roberts, A., Tang, T., Stewart, F., Pallini, C., Wallace, G., Cooper, A., Scott, A., Thickett, D., Lugg, S., Pinkney, T., Taylor, G., Brock, K., Stamataki, Z., Brady, C., Curnow, J., Gordon, J., Qureshi, O., Barnes, N., Bentley, L., Juvvanapudi, J., & 7 othersBancroft, H., Hemming, B., Ferris, C., Langman, G., Robinson, A., Chapman, J. & Naidu, B., 17 Feb 2021, In: Scientific Reports. 11, 1, 4030.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

203 Downloads (Pure)

Immediate sample fixation increases Circulating Tumour Cell (CTC) capture and preserves phenotype in head and neck squamous cell carcinoma: towards a standardised approach to microfluidic CTC biomarker discovery

Payne, K., Brooks, J., Taylor, G., Batis, N., Noyvert, B., Pan, Y., Nankivell, P. & Mehanna, H., 3 Nov 2021, In: Cancers. 13, 21, 5519.

Research output: Contribution to journal › Article › peer-review

Open Access

File

92 Downloads (Pure)

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

Syrimi, E., Fennell, E., Richter, A., Vrljicak, P., Stark, R., Ott, S., Murray, P. G., Al-Abadi, E., Chikermane, A., Dawson, P., Hackett, S., Jyothish, D., Kanthimathinathan, H. K., Monaghan, S., Nagakumar, P., Scholefield, B. R., Welch, S., Khan, N., Faustini, S., Davies, K., & 3 othersZelek, W. M., Kearns, P. & Taylor, G. S., 19 Nov 2021, In: iScience. 24, 11, 103215.

Research output: Contribution to journal › Article › peer-review

Open Access

File

105 Downloads (Pure)

2020

BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines

Diepstraten, S. T., Chang, C., Tai, L., Gong, J-N., Lan, P., Dowell, A. C., Taylor, G. S., Strasser, A. & Kelly, G. L., 28 Jan 2020, In: Blood Advances. 4, 2, p. 356-366 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

189 Downloads (Pure)

Circulating tumour cell expression of immune-markers as prognostic and therapeutic biomarkers in head and neck squamous cell carcinoma: a systematic review and meta-analysis

Payne, K., Pugh, M., Brooks, J., Batis, N., Taylor, G., Nankivell, P. & Mehanna, H., 3 Nov 2020, In: International Journal of Molecular Sciences. 21, 21, p. 1-14 14 p., 8229.

Research output: Contribution to journal › Article › peer-review

Open Access

File

196 Downloads (Pure)

Factors associated with cytomegalovirus serostatus in young people in England: a cross-sectional study

Winter, J. R., Taylor, G., Thomas, O., Jackson, C., Lewis, J. E. A. & Stagg, H. R., 23 Nov 2020, In: BMC Immunology. 20, 875 .

Research output: Contribution to journal › Article › peer-review

Open Access

File

180 Downloads (Pure)

Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature

Winter, J. R., Jackson, C., Lewis, J. E. A., Taylor, G. S., Thomas, O. G. & Stagg, H. R., 1 Jun 2020, In: Journal of Global Health. 10, 1, 010404.

Research output: Contribution to journal › Article › peer-review

Open Access

Risk factors for Epstein Barr virus-associated cancers: A systematic review, critical appraisal, and mapping of the epidemiological evidence

Bakkalci, D., Jia, Y., Winter, J. R., Lewis, J. E. A., Taylor, G. S. & Stagg, H. R., 1 Jun 2020, In: Journal of Global Health. 10, 1, 010405.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Circulating tumour cell biomarkers in head and neck cancer: Current progress and future prospects

Payne, K., Brooks, J., Spruce, R., Batis, N., Taylor, G., Nankivell, P. & Mehanna, H., Aug 2019, In: Cancers. 11, 8, 1115.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Citations (Scopus)

Heterologous prime-boost vaccination protects against EBV antigen-expressing lymphomas

Ruhl, J., Citterio, C., Engelmann, C., Haigh, T., Dzionek, A., Dreyer, J., Khanna, R., Taylor, G., Wilson, J., Leung, C. & Munz, C., 1 May 2019, In: Journal of Clinical Investigation. 129, 5, p. 2071-2087 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

22 Citations (Scopus)

153 Downloads (Pure)

Modelling the dynamics of EBV transmission to inform a vaccine target product profile and future vaccination strategy

Goscé, L., Winter, J. R., Taylor, G. S., Lewis, J. E. A. & Stagg, H. R., 26 Jun 2019, In: Scientific Reports. 9, 1, 9290.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

146 Downloads (Pure)

Predictors of Epstein-Barr virus serostatus in young people in England

Winter, J. R., Taylor, G. S., Thomas, O. G., Jackson, C., Lewis, J. E. A. & Stagg, H. R., 28 Nov 2019, In: BMC Infectious Diseases. 19, 1, 1007.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

186 Downloads (Pure)

Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma

Vockerodt, M., Vrzalikova, K., Ibrahim, M., Nagy, E., Margielewska, S., Hollows, R., Lupino, L., Tooze, R., Care, M., Simmons, W., Schrader, A., Perry, T., Abdullah, M., Foster, S., Reynolds, G., Dowell, A., Rudzki, Z., Krappmann, D., Kube, D., Woodman, C., & 3 othersWei, W., Taylor, G. & Murray, P. G., Jun 2019, In: Journal of Pathology. 248, 2, p. 142-154 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

The T-cell Response to Epstein-Barr Virus-New Tricks From an Old Dog

Long, H. M., Meckiff, B. J. & Taylor, G. S., 18 Sept 2019, In: Frontiers in immunology. 10, 2193.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

14 Citations (Scopus)

161 Downloads (Pure)

2017

EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus

Jiang, L., Lan, R., Huang, T., Chan, C. F., Li, H., Lear, S., Zong, J., Wong, W. Y., Muk-Lan Lee, M., Dow Chan, B., Chan, W. L., Lo, W. S., Mak, N. K., Li Lung, M., Lok Lung, H., Wah Tsao, S., Taylor, G. S., Bian, Z. X., Tai, W. C. S., Law, G. L., & 3 othersWong, W. T., Cobb, S. L. & Wong, K. L., 13 Mar 2017, In: Nature Biomedical Engineering. 1, 4, 0042.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer

Dowell, A., Cobby, E., Wen, K., Devall, A., During, V., Anderson, J., James, N., Cheng, K., Zeegers, M., Bryan, R. & Taylor, G., 20 Sept 2017, In: PLoS ONE. 12, 9, e0184841.

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (Scopus)

169 Downloads (Pure)

2016

Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination

Brooks, J., Long, H., Tierney, R., Shannon-Lowe, C., Leese, A., Fitzpatrick, M., Taylor, G. & Rickinson, A., 20 Apr 2016, In: PLoS pathogens. 12, 4, p. 1 25 p., e1005549.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

269 Downloads (Pure)

Therapeutic vaccination strategies to treat nasopharyngeal carcinoma

Taylor, G. S. & Steven, N. M., 1 Apr 2016, In: Chinese Clinical Oncology. 5, 2, 23.

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

2015

Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma

Yap, L. F., Velapasamy, S., Lee, H. M., Thavaraj, S., Rajadurai, P., Wei, W., Vrzalikova, K., Ibrahim, M. H., Khoo, A. S-B., Tsao, S. W., Paterson, I. C., Taylor, G. S., Dawson, C. W. & Murray, P. G., Feb 2015, In: Journal of Pathology. 235, 3, p. 456-65 10 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

T-Cell Responses to EBV

Hislop, A. D. & Taylor, G. S., 2015, In: Current Topics in Microbiology and Immunology. 391, p. 325-53 29 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

The immunology of Epstein-Barr virus-induced disease

Taylor, G. S., Long, H. M., Brooks, J. M., Rickinson, A. B. & Hislop, A. D., Mar 2015, In: Annual review of immunology. 33, p. 787-821 35 p.

Research output: Contribution to journal › Article › peer-review

219 Citations (Scopus)

2014

A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer

Taylor, G. S., Jia, H., Harrington, K., Lee, L. W., Turner, J. E., Ladell, K., Price, D. A., Tanday, M., Matthews, J., Roberts, C., Edwards, C., McGuigan, L., Hartley, A., Wilson, S., Hui, E. P., Chan, A. T. C., Rickinson, A. B. & Steven, N. M., 1 Oct 2014, In: Clinical Cancer Research. 20, 19, p. 5009-5022 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

68 Citations (Scopus)

294 Downloads (Pure)

2013

Epstein-barr virus: Opportunities for prophylactic and therapeutic vaccines

Turner, J. E. & Taylor, G. S., 17 Sept 2013, In: Microbiology Today. 40, 1, p. 34-37 4 p.

Research output: Contribution to journal › Article › peer-review

Phase I Trial of Recombinant Modified Vaccinia Ankara Encoding Epstein-Barr Viral Tumor Antigens in Nasopharyngeal Carcinoma Patients

Hui, E. P., Taylor, G. S., Jia, H., Ma, B. B. Y., Chan, S. L., Ho, R., Wong, W-L., Wilson, S., Johnson, B. F., Edwards, C., Stocken, D. D., Rickinson, A. B., Steven, N. M. & Chan, A. T. C., 15 Mar 2013, In: Cancer Research. 73, 6, p. 1676-1688 13 p.

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205

Leung, C. S., Maurer, M. A., Meixlsperger, S., Lippmann, A., Cheong, C., Zuo, J., Haigh, T. A., Taylor, G. S. & Münz, C., 28 Feb 2013, In: Blood. 121, 9, p. 1584-94 11 p.

Research output: Contribution to journal › Article › peer-review