Research output per year
Research output per year
Personal profile
Research interests
Dr Andrew Bell is a Research Fellow in the Institute of Cancer and Genomics. His research aims to understand how Epstein-Barr virus, a common herpesvirus with oncogenic properties, contributes to the development of several human malignancies. This work is funded by Cancer Research UK and involves collaborations with other members of the Centre for Human Virology.
EBV infection in healthy individuals
EBV establishes a persistent asymptomatic infection in the B cell system. I am interested in understanding how EBV exploits the natural process of B cell differentiation to gain access to the long-lived memory B cell pool while evading the host immune system.
EBV-driven B cell transformation
A clue to EBV’s role in lymphoma development comes from the observation that EBV can transform normal B lymphocytes in vitro into continuously growing lymphoblastoid cells. My work aims to understand how different viral genes contribute to this growth transformation process and identify virus-induced cellular changes that might be relevant to EBV-associated diseases.
EBV-associated B cell lymphomas
EBV is linked to a remarkable range of malignancies of B cell and epithelial cell origin. I am particularly interested in how EBV contributes to the development of four B cell lymphomas: post- transplant lymphoproliferative disease, diffuse large B cell lymphoma, Hodgkin lymphoma and Burkitt lymphoma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD Biochemistry, The University of Birmingham
Award Date: 8 Jul 1990
BSc (Hons) Biochemistry, The University of Birmingham
Award Date: 12 Jul 1987
Keywords
- QR355 Virology
- Tumour viruses
- Epstein-Barr virus
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- 1 Similar Profiles
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BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK cell lymphoma
Sejic, N., George, L., Tierney, R., Chang, C., Kondrashova, O., MacKinnon, R. N., Lan, P., Bell, A., Lessene, G., Long, H., Strasser, A., Shannon-Lowe, C. & Kelly, G. L., 13 Oct 2020, In: Blood Advances. 4, 19, p. 4775-4787 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)158 Downloads (Pure) -
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins
Fitzsimmons, L., Cartlidge, R., Chang, C., Sejic, N., Galbraith, L. C. A., Suraweera, C. D., Croom-Carter, D., Dewson, G., Tierney, R., Bell, A., Shannon-Lowe, C., Herold, M., Rickinson, A., Colman, P. M., Huang, D. C. S., Strasser, A., Kvansakul, M., Rowe, M. & Kelly, G. L., 23 Oct 2019, In: Cell Death & Differentiation . 27, 5, p. 1554-1568 15 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Asymptomatic primary infection with Epstein-Barr virus: observations on young adult cases
Abbott, R., Pachnio, A., Pedroza-Pacheco, I., Leese, A., Begum, J., Long, H., Croom-Carter, D., Stacey, A., Moss, P., Hislop, A., Borrow, P., Rickinson, A. & Bell, A., Nov 2017, In: Journal of virology. 91, 21, e00382-17.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)255 Downloads (Pure) -
Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells
Fitzsimmons, L., Boyce, A. J., Wei, W., Chang, C., Croom-Carter, D., Tierney, R. J., Herold, M. J., Bell, A. I., Strasser, A., Kelly, G. L. & Rowe, M., 29 Sept 2017, (E-pub ahead of print) In: Cell Death & Differentiation .Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)186 Downloads (Pure) -
Epstein-Barr virus-associated lymphomas
Shannon-Lowe, C., Rickinson, A. & Bell, A., 11 Sept 2017, In: Philosophical Transactions of the Royal Society of London Series B. 372, 1732, 20160271.Research output: Contribution to journal › Article › peer-review
Open AccessFile112 Citations (Scopus)302 Downloads (Pure)
Projects
- 11 Finished
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Challenging the dogma of latency in Epstein-Barr virus associated diseases: are there more 'latent' genes than we thought?
Bell, A. (Principal Investigator) & Fitzsimmons, L. (Co-Investigator)
13/06/16 → 12/08/16
Project: Research
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(60 MTHS) Epstein-Barr Virus Infections and Lymphomagenesis
Bell, A. (Principal Investigator)
1/01/13 → 30/04/18
Project: Research
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Studies on the Role of miRNAs as Effectors of Epstein-Barr Virus Induced Cellular Transformation and Oncogenesis
Rowe, M. (Principal Investigator) & Bell, A. (Co-Investigator)
1/10/08 → 30/09/12
Project: Research
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Epstein-Barr Virus Infections of B Lymphocytes and the Pathogenesis of Virus-Associated Lymphomas
Rickinson, A. (Principal Investigator), Bell, A. (Co-Investigator) & Rowe, M. (Co-Investigator)
1/01/08 → 31/12/12
Project: Research
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Studies of the Role of Epstein-Barr Virus in Burkitt's Lymphoma Using Subclones of a BL Line with Distinct Patterns of Virus Gene Expression
Bell, A. (Principal Investigator) & Rowe, M. (Co-Investigator)
1/10/06 → 30/09/10
Project: Research
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Lab tour for Cancer Research UK Legacy Event
Bell, A. (Presenter)
4 Jul 2017Activity: Engagement and Public events › Engagement event
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Lab tour for Cancer Research UK personal donors
Bell, A. (Presenter)
6 Dec 2016Activity: Engagement and Public events › Engagement event
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17th International symposium of Epstein-Barr virus and associated diseases
Bell, A. (Member of Programme Committee)
8 Aug 2016 → 12 Aug 2016Activity: Academic and Industrial events › Conference, workshop or symposium