Andrew Bell

Dr.

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Andrew Bell is a member of a research team interested in the biology of EBV and its role in lymphomagenesis. His work addresses the following areas: EBV persistence in normal healthy individuals The effects of EBV infection on cellular phenotype Virus gene expression in different cell types The role of EBV in lymphomagenesis Dr Bell supervises a number of PhD researchers studying the biology of Epstein Barr virus (EBV) and the pathogenesis of EBV-associated lymphomas

1989 …2020

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Research interests

Dr Andrew Bell is a Research Fellow in the Institute of Cancer and Genomics. His research aims to understand how Epstein-Barr virus, a common herpesvirus with oncogenic properties, contributes to the development of several human malignancies. This work is funded by Cancer Research UK and involves collaborations with other members of the Centre for Human Virology.

EBV infection in healthy individuals

EBV establishes a persistent asymptomatic infection in the B cell system. I am interested in understanding how EBV exploits the natural process of B cell differentiation to gain access to the long-lived memory B cell pool while evading the host immune system.

EBV-driven B cell transformation

A clue to EBV’s role in lymphoma development comes from the observation that EBV can transform normal B lymphocytes in vitro into continuously growing lymphoblastoid cells. My work aims to understand how different viral genes contribute to this growth transformation process and identify virus-induced cellular changes that might be relevant to EBV-associated diseases.

EBV-associated B cell lymphomas

EBV is linked to a remarkable range of malignancies of B cell and epithelial cell origin. I am particularly interested in how EBV contributes to the development of four B cell lymphomas: post- transplant lymphoproliferative disease, diffuse large B cell lymphoma, Hodgkin lymphoma and Burkitt lymphoma.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Award Date: 8 Jul 1990

Award Date: 12 Jul 1987

Keywords

  • QR355 Virology
  • Tumour viruses
  • Epstein-Barr virus

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