NIHR Biomedical Research Centre (BRC) - Core Theme

Research output

Research output per year 2021 2021 2022 2023 2023

• 18 Article
• 2 Review article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2023

  Concerns and expectations in women with polycystic ovary syndrome vary across age and ethnicity: findings from PCOS Pearls Study

  PCOS SEva Working Group, Elghobashy, M., Lau, G. M., Davitadze, M., Gillett, C., O'reilly, M., Arlt, W., Lindenmeyer, A. & Kempegowda, P., 9 Aug 2023, In: Frontiers in Endocrinology. 14, 8 p., 1175548.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polycystic Ovary Syndrome 100%
  • Motivation 72%
  • Mental Health 15%
  • Menstruation Disturbances 13%
  • Social Conditions 11%
  34 Downloads (Pure)

• Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

  Zhang, F., Jonsson, A. H., Nathan, A., Millard, N., Curtis, M., Xiao, Q., Gutierrez-Arcelus, M., Apruzzese, W., Watts, G. F. M., Weisenfeld, D., Nayar, S., Rangel-Moreno, J., Meednu, N., Marks, K. E., Mantel, I., Kang, J. B., Rumker, L., Mears, J., Slowikowski, K., Weinand, K., & 33 othersOrange, D. E., Geraldino-Pardilla, L., Deane, K. D., Tabechian, D., Ceponis, A., Firestein, G. S., Maybury, M., Sahbudin, I., Ben-Artzi, A., Mandelin II, A. M., Nerviani, A., Lewis, M. J., Rivellese, F., Pitzalis, C., Hughes, L. B., Horowitz, D., DiCarlo, E., Gravallese, E. M., Boyce, B. F., Accelerating Medicines Partnership (AMP) RA/SLE Network, Moreland, L. W., Goodman, S. M., Perlman, H., Holers, V. M., Liao, K. P., Filer, A., Bykerk, V. P., Wei, K., Rao, D. A., Donlin, L. T., Anolik, J. H., Brenner, M. B. & Raychaudhuri, S., 16 Nov 2023, In: Nature. 623, 7987, p. 616-624 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synovial Membrane 100%
  • Rheumatoid Arthritis 70%
  • Phenotype 23%
  • Atlases 16%
  • Histology 12%
  32 Downloads (Pure)

• Emotional and psychosexual wellbeing is influenced by ethnicity and birthplace in women and individuals with polycystic ovary syndrome in the UK and India

  Sheikh, J., Khalil, H., Shaikh, S., Hebbar, M., Zia, N., Wicks, S., Jayaprakash, S., Narendran, A., Subramanian, A., Malhotra, K., Chapman, R., Gillett, C., Gleeson, H., Robinson, L., Justin, C., Lathia, T., Selvan, C., O'reilly, M., Manolopoulos, K., Arlt, W., & 2 othersKempegowda, P. & PCOS SEva team, 8 Mar 2023, In: BJOG: An International Journal of Obstetrics & Gynaecology. 130, 8, p. 978-986

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polycystic Ovary Syndrome 100%
  • India 78%
  • 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester 39%
  • Body Image 25%
  • Depression 24%
  29 Downloads (Pure)

• Impaired lower limb muscle mass, quality and function in end stage liver disease: A cross‐sectional study

  Quinlan, J. I., Dhaliwal, A., Williams, F. R., Allen, S. L., Choudhary, S., Rowlands, A., Breen, L., Lavery, G. G., Lord, J. M., Elsharkawy, A. M., Armstrong, M. J. & Greig, C. A., 1 Aug 2023, In: Experimental Physiology. 108, 8, 1066-1079.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • End Stage Liver Disease 100%
  • Lower Extremity 68%
  • Muscles 51%
  • Quadriceps Muscle 28%
  • Skeletal Muscle 25%
  47 Downloads (Pure)

• Improving physiological relevance of cell culture: the possibilities, considerations, and future directions of the ex vivo coculture model

  Allen, S. L., Elliott, B. T., Carson, B. P. & Breen, L., 3 Feb 2023, In: AJP: Cell Physiology. 324, 2, p. C420-C427

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Coculture Techniques 100%
  • Cell Culture Techniques 76%
  • Direction compound 72%
  • Muscle Cells 61%
  • Hypertrophy 60%
  26 Downloads (Pure)

• Incretins (GLP-1 receptor agonists and dual/triple agonists) and the liver

  Newsome, P. N. & Ambery, P., 1 Dec 2023, In: Journal of Hepatology. 79, 6, p. 1557-1565

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gastric Inhibitory Polypeptide 100%
  • Incretins 88%
  • Glucagon-Like Peptide-1 Receptor 87%
  • Fatty Liver 72%
  • Insulin Resistance 55%
  1 Downloads (Pure)

• Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study

  Favero, V., Prete, A., Mangone, A., Elhassan, Y., Pucino, V., Asia, M., Hardy, R., Chiodini, I. & Ronchi, C., 23 Nov 2023, In: European Journal of Endocrinology. 183, p. 517-526 10 p., lvad151.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrocortisone 100%
  • Cushing Syndrome 77%
  • Inflammation 66%
  • Lymphocytes 39%
  • Neoplasms 36%
  21 Downloads (Pure)

• Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

  AFEF group for the study of liver fibrosis & M118 study group, 26 Aug 2023, In: Nature Communications. 14, 1, 11 p., 5219 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • fibrosis 100%
  • Blood Analysis 97%
  • liver 72%
  • Non-alcoholic Fatty Liver Disease 70%
  • Fibrosis 49%
  31 Downloads (Pure)

• Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis

  Sanyal, A. J., Ratziu, V., Loomba, R., Anstee, Q. M., Kowdley, K. V., Rinella, M. E., Y Sheikh, M., Trotter, J. F., Knapple, W., Lawitz, E. J., Abdelmalek, M. F., Newsome, P. N., Boursier, J., Mathurin, P., Dufour, J-F., Berrey, M. M., Shiff, S. J., Sawhney, S., Capozza, T., Leyva, R., & 2 othersHarrison, S. A. & Younossi, Z. M., Nov 2023, In: Journal of Hepatology. 79, 5, p. 1110-1120 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • obeticholic acid 100%
  • Fatty Liver 62%
  • Fibrosis 43%
  • Safety 33%
  • Liver Cirrhosis 16%
  54 Downloads (Pure)
• 2022

  A Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity

  Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T. A., Duggal, N. A. & Lord, J. M., 14 Oct 2022, (E-pub ahead of print) In: Physiological Reviews.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Frailty 100%
  • Phenotype 8%
  • Adiposity 7%
  • Life Expectancy 6%
  • Cardiovascular System 6%
  176 Downloads (Pure)

• Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease

  Lalor, P. F., Huser, T. & van Grunsven, L. A., 8 Mar 2022, In: Frontiers in Physiology. 13, 3 p., 869473.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  6 Downloads (Pure)

• Feasibility, Efficacy, and Safety of Percutaneous Muscle Biopsies in Patients With Chronic Liver Disease

  Quinlan, J. I., Dhaliwal, A., Williams, F., Allen, S. L., Breen, L., Greig, C. A., Lord, J. M., Armstrong, M. J. & Elsharkawy, A. M., 15 Feb 2022, In: Frontiers in Physiology. 12, 7 p., 817152.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • End Stage Liver Disease 100%
  • Liver Diseases 71%
  • Chronic Disease 62%
  • Non-alcoholic Fatty Liver Disease 52%
  • Biopsy 51%
  44 Downloads (Pure)

• Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study

  COV-AD consortium, 2 Jun 2022, In: Frontiers in immunology. 13, 912571.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Seroepidemiologic Studies 75%
  • Antibody Formation 60%
  • Immunization 57%
  • Vaccines 50%
  63 Downloads (Pure)

• Outcomes of periodontal therapy in rheumatoid arthritis: the OPERA feasibility randomized trial

  De Pablo, P., Serban, S., Lopez-Oliva, I., Rooney, J., Hill, K., Raza, K., Filer, A., Chapple, I. & Dietrich, T., 16 Dec 2022, In: Journal of Clinical Periodontology. 50, 3, p. 295-306

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rheumatoid Arthritis 100%
  • Periodontitis 43%
  • Dental Hygienists 29%
  • Periodontal Diseases 21%
  • Therapeutics 19%
  45 Downloads (Pure)

• Polycystic ovary syndrome and risk of adverse obstetric outcomes: a retrospective population-based matched cohort study in England

  Subramanian, A., Lee, S., Phillips, K., Toulis, K., Kempegowda, P., O'reilly, M., Adderley, N., Thangaratinam, S., Arlt, W. & Nirantharakumar, K., 30 Aug 2022, In: BMC medicine. 20, 1, 13 p., 298.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Polycystic Ovary Syndrome 100%
  • England 89%
  • Obstetrics 81%
  • Cohort Studies 61%
  • Population 35%
  35 Downloads (Pure)
• 2021

  11-oxygenated estrogens are a novel class of human estrogens but do not contribute to the circulating estrogen pool

  Barnard, L., Schiffer, L., Du-Toit, R. L., Tamblyn, J., Chen, S., Africander, D., Arlt, W., Foster, P. & Storbeck, K-H., Mar 2021, In: Endocrinology. 162, 3, bqaa231.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgens 100%
  • Estrogens 90%
  • Aromatase 38%
  • Estradiol 20%
  • 11-ketotestosterone 13%
  2 Citations (Scopus)

  169 Downloads (Pure)

• Clinical outcomes, predictors of prognosis and health economics consequences in IBD patients after discontinuation of the first biological therapy

  Shivaji, U., Bazarova, A., Critchlow, T., Smith, S. CL., Nardone, O., Love, M., Davis, J., Ghosh, S. & Iacucci, M., 1 Jan 2021, In: Therapeutic Advances in Gastroenterology. 13, p. 1-16

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Therapy 100%
  • Biological Products 83%
  • Inflammatory Bowel Diseases 79%
  • Economics 65%
  • Gastroenterologists 64%
  177 Downloads (Pure)

• Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

  Schiffer, L., Bossey, A., Kempegowda, P., Taylor, A., Akerman, I., Scheel-Toellner, D., Storbeck, K-H. & Arlt, W., 1 Mar 2021, In: European Journal of Endocrinology. 184, 3, p. 353–363 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Androgens 100%
  • Blood Cells 89%
  • 11-ketotestosterone 75%
  • Natural Killer Cells 27%
  • Steroids 16%
  180 Downloads (Pure)

• Relationship Between Inflammation and Metabolism in Patients With Newly Presenting Rheumatoid Arthritis

  Jutley, G. S., Sahota, K., Sahbudin, I., Filer, A., Arayssi, T., Young, S. P. & Raza, K., 28 Sept 2021, In: Frontiers in immunology. 12, 676105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • C-Reactive Protein 100%
  • Rheumatoid Arthritis 93%
  • Inflammation 66%
  • Metabolome 54%
  • Metabolomics 53%
  95 Downloads (Pure)

• Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

  Shields, A. M., Faustini, S. E., Perez-Toledo, M., Jossi, S., Allen, J. D., Al-Taei, S., Backhouse, C., Dunbar, L. A., Ebanks, D., Emmanuel, B., Faniyi, A. A., Garvey, M., Grinbergs, A., McGinnell, G., O'Neill, J., Watanabe, Y., Crispin, M., Wraith, D. C., Cunningham, A. F., Drayson, M. T., & 1 othersRichter, A. G., 24 Sept 2021, In: BMJ Open Respiratory Research. 8, 1, e000872.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Antibody Formation 60%
  • Glycoproteins 57%
  • Immunoglobulin G 41%
  • Immunoglobulin A 38%
  41 Downloads (Pure)

• The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging

  Allen, S. L., Marshall, R. N., Edwards, S. J., Lord, J. M., Lavery, G. G. & Breen, L., 1 Jul 2021, In: AJP: Cell Physiology. 321, 1, p. C26-C37 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Skeletal Muscle Fibers 100%
  • Muscle Proteins 75%
  • Growth 57%
  • Serum 52%
  • In Vitro Techniques 50%
  137 Downloads (Pure)