Research output per year
Research output per year
Personal profile
Research interests
My team uses a range of methods of both molecular and cellular immunology to explore the roles of immune cell populations in samples taken directly from sites of inflammation.
The overarching aim of our work is to identify novel clinical targets for the improved therapy of chronic inflammatory disease.
We recently identified a novel FcRL4+ B cell population in the rheumatoid joint and in other inflammatory diseases. Our findings suggest a pro-inflammatory and destructive role for this cell type, it is specifically involved in the local autoimmune response. Investigation of their origin, differentiation, role in inflammatory diseases and potential as a clinical target is now an important focus of our work.
Biography
After qualifying as a pharmacist, I studied for a PhD in Immunology and Pharmaceutical Biology with Professor Johannes Gerdes at the University of Kiel (awarded summa cum laude). I then joined the Department of Rheumatology at the University of Birmingham as a Research Fellow.
In 2004 I was awarded a 5 year Career Development Fellowship, followed by a Career Progression Fellowship by Arthritis Research UK leading to a tenured post as a Senior Research Fellow. In 2015 I was promoted to Reader.
Qualifications
Registered Pharmacist, University of Kiel, Germany
Dr rer. nat. (PhD in Immunology and Pharmaceutical Biology)
Member of the Higher Education Academy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Characterization of age-associated B cells in early drug-naïve rheumatoid arthritis patients
Vidal-Pedrola, G., Naamane, N., Cameron, J. A., Pratt, A. G., Mellor, A. L., Isaacs, J. D., Scheel-Toellner, D. & Anderson, A. E., Apr 2023, In: Immunology. 168, 4, p. 640-653 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens
Schiffer, L., Bossey, A., Kempegowda, P., Taylor, A., Akerman, I., Scheel-Toellner, D., Storbeck, K-H. & Arlt, W., 1 Mar 2021, In: European Journal of Endocrinology. 184, 3, p. 353–363 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile129 Downloads (Pure) -
The Role of B Cells in Adult and Paediatric Liver Injury
Patel, A. M., Liu, Y. S., Davies, S. P., Brown, R. M., Kelly, D. A., Scheel-toellner, D., Reynolds, G. M. & Stamataki, Z., 23 Sept 2021, In: Frontiers in immunology. 12, 729143.Research output: Contribution to journal › Article › peer-review
Open AccessFile143 Downloads (Pure) -
Development of a Tool to Assess Synovial Tissue Infiltrates and Derive Histological Pathotype in Inflammatory Arthritis: Relationship to Clinical and Ultrasound Variables
Carr, H., Sahbudin, I., Maybury, M., Dyke, B., Turner, J., Gullick, N., Raza, K., Scheel-Toellner, D. & Filer, A., 2020, In: Arthritis & Rheumatology.Research output: Contribution to journal › Article
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New developments in transcriptomic analysis of synovial tissue
Carr, H. L., Turner, J. D., Major, T., Scheel-Toellner, D. & Filer, A., 31 Jan 2020, In: Frontiers in Medicine. 7, 21.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)113 Downloads (Pure)
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Synovial lymphocyte diversity and origin in childhood onset arthritis
Croft, A. & Scheel-Toellner, D.
DAPHNE JACKSON MEMORIAL FELLOWSHIP TRUST
15/05/23 → 14/05/26
Project: Research
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AIM-for-RA
Raza, K., Scheel-Toellner, D., McGettrick, H., Clark, A. & Filer, A.
NATIONAL INSTITUTE OF HEALTH, USA
22/03/22 → 31/12/26
Project: Research
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Rheumatoid Arthritis Centre for Excellence (RACE 2)
Filer, A., Lord, J., Raza, K., Scheel-Toellner, D., Anderson, G., Buckley, C., Clark, A. & Falahee, M.
1/04/19 → 30/09/25
Project: Research
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BREATHE – B cell Receptor Evaluation for Antibodies to protect Human Exposure to SARS-CoV-2
Scheel-Toellner, D. & Richter, A.
1/07/20 → 30/06/21
Project: Research