Timothy Barrett

Accepting PhD Students

PhD projects

Timothy Barrett is Professor of Paediatrics, Honorary Consultant in Paediatric Endocrinology and Diabetes, and Program Director for the Wellcome Trust Clinical Research Facility at Birmingham Children’s Hospital. He has published over 100 research papers in scientific journals as well as reviews and book chapters in the fields of paediatrics, diabetes and genetics of childhood diabetes syndromes. He has received major grants from The Medical Research Council, The Wellcome Trust, European Union Directorate General for Health and Consumer Affairs, Diabetes UK and Wellchild. He leads NHS national specialist commissioned services in rare diabetes syndromes, and a busy clinical practice of general diabetes, type 2 diabetes in children, and tertiary endocrinology. He is an enthusiastic teacher and communicator on the theme of childhood diabetes, and lectures widely at national and international level. Timothy contributes to the local and national media and advises the BBC on stories relating to childhood obesity and metabolism.

Professor Barrett is currently supervising two students for PhD on genetics and functional studies in rare diabetes disorders.

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Fingerprint

Dive into the research topics where Timothy Barrett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

1 Similar Profiles

Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT
Adams, R., Jordan, R., Maher, A., Adab, P., Barrett, T., Bevan, S., Cooper, L., DuRand, I., Edwards, F., Hardy, P., Harris, C., Heneghan, N. R., Jolly, K., Jowett, S., Marshall, T., O'Hara, M., Poyner, C., Rai, K., Rickards, H. & Riley, R. & 5 others, Ives, N., Sadhra, S., Tearne, S., Walters, G. & Sapey, E., 31 Aug 2024, In: Health and Social Care Delivery Research. 12, 23, p. 1-105 105 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
11 Downloads (Pure)
Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons
Korsgen, M. E., Sun, C., Seranova, E., Zatyka, M., Astuti, D., Kataura, T., Barrett, T., Korolchuk, V. I. & Sarkar, S., 25 Aug 2023, (E-pub ahead of print) In: STAR Protocols. 4, 3, 102529.
Research output: Contribution to journal › Article › peer-review

Open Access
File
34 Downloads (Pure)
Current evidence for designing self-management support for underserved populations: an integrative review using the example of diabetes
Litchfield, I., Barrett, T., Hamilton-Shield, J., Moore, T., Narendran, P., Redwood, S., Searle, A., Uday, S., Wheeler, J. & Greenfield, S., 11 Sept 2023, In: International Journal for Equity in Health. 22, 1, 16 p., 188.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
108 Downloads (Pure)
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome
Zatyka, M., Rosenstock, T. R., Sun, C., Palhegyi, A. M., Hughes, G. W., Lara-Reyna, S., Astuti, D., di Maio, A., Sciauvaud, A., Korsgen, M. E., Stanulovic, V., Kocak, G., Rak, M., Pourtoy-Brasselet, S., Winter, K., Varga, T., Jarrige, M., Polvèche, H., Correia, J. & Frickel, E.-M. & 5 others, Hoogenkamp, M., Ward, D. G., Aubry, L., Barrett, T. & Sarkar, S., 9 May 2023, In: Stem Cell Reports. 18, 5, p. 1090-1106 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
47 Downloads (Pure)
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
Sun, C., Seranova, E., Cohen, M. A., Chipara, M., Roberts, J., Astuti, D., Palhegyi, A. M., Acharjee, A., Sedlackova, L., Kataura, T., Otten, E. G., Panda, P. K., Lara-Reyna, S., Korsgen, M. E., Kauffman, K. J., Huerta-Uribe, A., Zatyka, M., Silva, L. F. S. E., Torresi, J. & Zhang, S. & 20 others, Hughes, G. W., Ward, C., Kuechler, E. R., Cartwright, D., Trushin, S., Trushina, E., Sahay, G., Buganim, Y., Lavery, G. G., Gsponer, J., Anderson, D. G., Frickel, E. M., Rosenstock, T. R., Barrett, T., Maddocks, O. D. K., Tennant, D. A., Wang, H., Jaenisch, R., Korolchuk, V. I. & Sarkar, S., 30 May 2023, In: Cell Reports. 42, 5, 26 p., 112372.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

96 Downloads (Pure)

10 Active
46 Finished

Combination treatment strategy with autophagy inducer and NAD booster for rare childhood-onset neurodegenerative diseases
Barrett, T. (Co-Investigator) & Sarkar, S. (Principal Investigator)
ACTION MEDICAL RESEARCH
1/11/24 → 31/10/27
Project: Research
Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases
Barrett, T. (Co-Investigator) & Sarkar, S. (Principal Investigator)
Medical Research Council
1/10/24 → 30/09/27
Project: Research Councils
LifeArc Translational Rare Disease Centre RD-TAP
Calvert, M. (Co-Investigator), Blackburn, S. (Co-Investigator), Billingham, L. (Co-Investigator), Harper, L. (Co-Investigator), Kearns, P. (Co-Investigator), Gates, S. (Co-Investigator), Aiyegbusi, L. (Co-Investigator), Trivedi, P. (Co-Investigator), Gkoutos, G. (Co-Investigator), Homer, V. (Co-Investigator), Barrett, T. (Principal Investigator), Retzer, A. (Co-Investigator) & Higgs, M. (Co-Investigator)
LifeArc
1/09/24 → 31/08/29
Project: Research
Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia
Stewart, G. (Co-Investigator), Barrett, T. (Co-Investigator), Sarkar, S. (Co-Investigator) & Tuxworth, R. (Principal Investigator)
ACTION FOR A-T
1/07/24 → 28/02/27
Project: Research
Changing clinical practice in rare diseases through innovative trial designs: the CAPTIVATE node
Barrett, T. (Co-Investigator), Homer, V. (Co-Investigator), Gates, S. (Co-Investigator), Kearns, P. (Co-Investigator) & Billingham, L. (Principal Investigator)
Medical Research Council
3/07/23 → 2/07/28
Project: Research Councils

1 Conference, workshop or symposium

Assessing the design of our trial in an ultra-rare condition by the Parmar et al framework for trials in smaller populations
Brock, K. (Speaker), Billingham, L. (Contributor), Yap, C. (Contributor) & Barrett, T. (Contributor)
10 Jul 2017
Activity: Academic and Industrial events › Conference, workshop or symposium

Timothy Barrett

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT

Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons

Current evidence for designing self-management support for underserved populations: an integrative review using the example of diabetes

Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

Combination treatment strategy with autophagy inducer and NAD booster for rare childhood-onset neurodegenerative diseases

Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases

LifeArc Translational Rare Disease Centre RD-TAP

Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia

Changing clinical practice in rare diseases through innovative trial designs: the CAPTIVATE node

Assessing the design of our trial in an ultra-rare condition by the Parmar et al framework for trials in smaller populations

Timothy Barrett

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Activities