Ruth Densham

Research output

Research output per year 2004 2009 2018 2019 2022

• 15 Article
• 1 Review article
• 1 Preprint

Research output per year

Research output per year

Search results

• 2022

  Imaging nanoscale nuclear structures with expansion microscopy

  Faulkner, E., Pike, J., Densham, R., Garlick, E., Thomas, S., Neely, R. & Morris, J., 19 Jul 2022, In: Journal of Cell Science. 135, 14, 11 p., jcs259009.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microscopy 100%
  • Tumor Suppressor p53-Binding Protein 1 70%
  • DNA Damage 69%
  • BRCA1 Protein 59%
  • Chromatin 35%
  83 Downloads (Pure)
• 2019

  BRCA1-BARD1: the importance of being in shape

  Daza-martin, M., Densham, R. M. & Morris, J. R., 2 Nov 2019, In: Molecular and Cellular Oncology. 6, 6, e1656500.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Recombinational DNA Repair 100%
  • BRCA1 Protein 38%
  • Genome 17%
  3 Citations (Scopus)

  239 Downloads (Pure)

• Isomerization of BRCA1-BARD1 promotes replication fork protection

  Daza-Martin, M., Starowicz, K., Jamshad, M., Tye, S., Ronson, G. E., MacKay, H. L., Chauhan, A. S., Walker, A. K., Stone, H. R., Beesley, J. F. J., Coles, J. L., Garvin, A. J., Stewart, G. S., McCorvie, T. J., Zhang, X., Densham, R. M. & Morris, J. R., 25 Jul 2019, In: Nature. 571, 7766, p. 521-527

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homologous Recombination 100%
  • Fanconi Anemia Complementation Group Proteins 73%
  • Peptidylprolyl Isomerase 63%
  • Phosphorylation 30%
  • Genome 30%
  31 Citations (Scopus)

  695 Downloads (Pure)

• The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms

  Garvin, A. J., Walker, A. K., Densham, R. M., Chauhan, A. S., Stone, H. R., Mackay, H. L., Jamshad, M., Starowicz, K., Daza-Martin, M., Ronson, G. E., Lanz, A. J., Beesley, J. F. & Morris, J. R., 1 Mar 2019, In: Genes & Development. 33, 5-6, p. 333-347 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 100%
  • Sumoylation 92%
  • Homologous Recombination 77%
  • Personnel Selection 51%
  • Double-Stranded DNA Breaks 39%
  12 Citations (Scopus)

  278 Downloads (Pure)
• 2018

  Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11

  Spiliotopoulos, A., Blokpoel Ferreras, L., Densham, R. M., Caulton, S. G., Maddison, B. C., Morris, J. R., Dixon, J. E., Gough, K. C. & Dreveny, I., 29 Oct 2018, (E-pub ahead of print) In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Deubiquitinating Enzymes 100%
  • Ubiquitin 72%
  • Binding Sites 55%
  • Ligands 50%
  • Peptides 45%
  11 Citations (Scopus)

  133 Downloads (Pure)

• USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

  Uckelmann, M., Densham, R. M., Baas, R., Winterwerp, H. H. K., Fish, A., Sixma, T. K. & Morris, J. R., Dec 2018, In: Nature Communications. 9, 1, 16 p., 229.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-Specific Proteases 100%
  • protease 99%
  • Camptothecin 85%
  • Histone 71%
  • cleavage 68%
  29 Citations (Scopus)

  288 Downloads (Pure)
• 2017

  The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

  Densham, R. M. & Morris, J. R., 2017, In: Nucleus (Austin). 8, p. 116-125

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-Protein Ligases 100%
  • Ligases 96%
  • Ubiquitin 88%
  • DNA Repair 81%
  • Chromatin Assembly and Disassembly 51%
  21 Citations (Scopus)

  175 Downloads (Pure)
• 2016

  Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

  Densham, R. M., Garvin, A. J., Stone, H. R., Strachan, J., Baldock, R. A., Daza-Martin, M., Fletcher, A., Blair-Reid, S., Beesley, J., Johal, B., Pearl, L. H., Neely, R., Keep, N. H., Watts, F. Z. & Morris, J. R., Jul 2016, In: Nature Structural and Molecular Biology. 23, 7, p. 647-655 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ligases 100%
  • Ubiquitin 91%
  • Chromatin 80%
  • DNA 50%
  • DNA Repair 50%
  114 Citations (Scopus)

  513 Downloads (Pure)
• 2013

  The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

  Garvin, A. J., Densham, R. M., Blair-Reid, S. A., Pratt, K. M., Stone, H. R., Weekes, D., Lawrence, K. J. & Morris, J., 10 Sept 2013, In: EMBO Reports. 14, p. 975-983

  Research output: Contribution to journal › Article › peer-review

  • Recombinational DNA Repair 100%
  • Chromatin 68%
  • Protein 31%
  • Double-Stranded DNA 27%
  • Mammalian Cell 26%
  56 Citations (Scopus)
• 2012

  The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response

  Butler, L. R., Densham, R. M., Jia, J., Garvin, A. J., Stone, H. R., Shah, V., Weekes, D., Festy, F., Beesley, J. & Morris, J., 2012, In: The EMBO journal. 31, 19, p. 3918-34 17 p.

  Research output: Contribution to journal › Article › peer-review

  • ubiquitin isopeptidase 100%
  • Double-Stranded DNA Breaks 62%
  • Proteasome Endopeptidase Complex 57%
  • Ubiquitin 55%
  • Polyubiquitin 53%
  91 Citations (Scopus)
• 2009

  MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability

  Densham, R. M., O'Neill, E., Munro, J., König, I., Anderson, K., Kolch, W. & Olson, M. F., Dec 2009, In: Molecular and Cellular Biology. 29, 24, p. 6380-90 11 p.

  Research output: Contribution to journal › Article › peer-review

  • actin kinase 100%
  • JNK Mitogen-Activated Protein Kinases 63%
  • Phosphotransferases 43%
  • Actin Cytoskeleton 27%
  • Actins 23%
  62 Citations (Scopus)

• The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

  Morris, J., Boutell, C., Keppler, M., Densham, R., Weekes, D., Alamshah, A., Butler, L., Galanty, Y., Pangon, L., Kiuchi, T., Ng, T. & Solomon, E., 17 Dec 2009, In: Nature. 462, 7275, p. 886-890 5 p.

  Research output: Contribution to journal › Article

  • Ubiquitin 100%
  • DNA Damage 86%
  • Ligases 54%
  • Sumoylation 13%
  • Ubiquitin-Protein Ligases 11%
  312 Citations (Scopus)
• 2008

  ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover

  Densham, R. M., Todd, D. E., Balmanno, K. & Cook, S. J., Nov 2008, In: Cellular Signalling. 20, 11, p. 1986-94 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin D1 100%
  • Gastrin-Secreting Cells 72%
  • Cell Cycle Checkpoints 54%
  • Phosphorylation 51%
  • Cell Cycle 43%
  14 Citations (Scopus)
• 2006

  Stability of p21^Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton

  Coleman, M. L., Densham, R. M., Croft, D. R. & Olson, M. F., 4 May 2006, In: Oncogene. 25, 19, p. 2708–2716

  Research output: Contribution to journal › Article › peer-review

  • Actin Cytoskeleton 100%
  • Actins 85%
  • Proteins 37%
  • ras Proteins 25%
  • Protein Stability 23%
  32 Citations (Scopus)
• 2004

  ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

  Todd, D. E., Densham, R. M., Molton, S. A., Balmanno, K., Newson, C., Weston, C. R., Garner, A. P., Scott, L. & Cook, S. J., 22 Apr 2004, In: Oncogene. 23, 19, p. 3284-95 12 p.

  Research output: Contribution to journal › Article › peer-review

  • G1 Phase Cell Cycle Checkpoints 100%
  • Cell Cycle 45%
  • Serum 26%
  • 3T3 Cells 25%
  • MAP Kinase Signaling System 21%
  72 Citations (Scopus)