Research output per year
Research output per year
- 19 results
Search results
-
2025
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Garvin, A. J., Lanz, A. J., Ronson, G. E., Mackintosh, M. J. W., Starowicz, K., Walker, A. K., Aghabi, Y., MacKay, H., Densham, R. M., Bhachoo, J. S., Leney, A. C. & Morris, J. R., 6 Mar 2025, In: Molecular Cell. 85, 5, p. 877-893.e9 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Downloads (Pure) -
2024
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication
Mackay, H. L., Stone, H. R., Ronson, G. E., Ellis, K., Lanz, A., Aghabi, Y., Walker, A. K., Starowicz, K., Garvin, A. J., Van Eijk, P., Koestler, S. A., Anthony, E. J., Piberger, A. L., Chauhan, A. S., Conway-Thomas, P., Vaitsiankova, A., Vijayendran, S., Beesley, J. F., Petermann, E. & Brown, E. J. & 5 others, , 16 Sept 2024, In: Nature Communications. 15, 17 p., 8102.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
2022
Imaging nanoscale nuclear structures with expansion microscopy
Faulkner, E., Pike, J., Densham, R., Garlick, E., Thomas, S., Neely, R. & Morris, J., 19 Jul 2022, In: Journal of Cell Science. 135, 14, 11 p., jcs259009.Research output: Contribution to journal › Article › peer-review
Open AccessFile190 Downloads (Pure) -
2021
Imaging nanoscale nuclear structures with expansion microscopy
Faulkner, E. L., Pike, J. A., Densham, R. M., Garlick, E., Thomas, S. G., Neely, R. K. & Morris, J. R., 4 May 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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2019
BRCA1-BARD1: the importance of being in shape
Daza-martin, M., Densham, R. M. & Morris, J. R., 2 Nov 2019, In: Molecular and Cellular Oncology. 6, 6, e1656500.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)311 Downloads (Pure) -
Isomerization of BRCA1-BARD1 promotes replication fork protection
Daza-Martin, M., Starowicz, K., Jamshad, M., Tye, S., Ronson, G. E., MacKay, H. L., Chauhan, A. S., Walker, A. K., Stone, H. R., Beesley, J. F. J., Coles, J. L., Garvin, A. J., Stewart, G. S., McCorvie, T. J., Densham, R. M., Morris, J. R. & Zhang, X., 25 Jul 2019, In: Nature. 571, 7766, p. 521-527Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)840 Downloads (Pure) -
Moving Mountains-The BRCA1 Promotion of DNA Resection
Densham, R. M. & Morris, J. R., 3 Sept 2019, In: Frontiers in Molecular Bioscience. 6, 79.Research output: Contribution to journal › Review article › peer-review
Open AccessFile11 Citations (Scopus)228 Downloads (Pure) -
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
Garvin, A. J., Walker, A. K., Densham, R. M., Chauhan, A. S., Stone, H. R., Mackay, H. L., Jamshad, M., Starowicz, K., Daza-Martin, M., Ronson, G. E., Lanz, A. J., Beesley, J. F. & Morris, J. R., 1 Mar 2019, In: Genes & Development. 33, 5-6, p. 333-347 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)320 Downloads (Pure) -
2018
Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11
Spiliotopoulos, A., Blokpoel Ferreras, L., Densham, R. M., Caulton, S. G., Maddison, B. C., Morris, J. R., Dixon, J. E., Gough, K. C. & Dreveny, I., 29 Oct 2018, (E-pub ahead of print) In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)170 Downloads (Pure) -
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
Uckelmann, M., Densham, R. M., Baas, R., Winterwerp, H. H. K., Fish, A., Sixma, T. K. & Morris, J. R., Dec 2018, In: Nature Communications. 9, 1, 16 p., 229.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)341 Downloads (Pure) -
2017
The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair
Densham, R. M. & Morris, J. R., 2017, In: Nucleus (Austin). 8, p. 116-125Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)222 Downloads (Pure) -
2016
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
Densham, R. M., Garvin, A. J., Stone, H. R., Strachan, J., Baldock, R. A., Daza-Martin, M., Fletcher, A., Blair-Reid, S., Beesley, J., Johal, B., Pearl, L. H., Neely, R., Keep, N. H., Watts, F. Z. & Morris, J. R., Jul 2016, In: Nature Structural and Molecular Biology. 23, 7, p. 647-655 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile114 Citations (Scopus)602 Downloads (Pure) -
2013
The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair
Garvin, A. J., Densham, R. M., Blair-Reid, S. A., Pratt, K. M., Stone, H. R., Weekes, D., Lawrence, K. J. & Morris, J., 10 Sept 2013, In: EMBO Reports. 14, p. 975-983Research output: Contribution to journal › Article › peer-review
56 Citations (Scopus) -
2012
The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response
Butler, L. R., Densham, R. M., Jia, J., Garvin, A. J., Stone, H. R., Shah, V., Weekes, D., Festy, F., Beesley, J. & Morris, J., 2012, In: The EMBO journal. 31, 19, p. 3918-34 17 p.Research output: Contribution to journal › Article › peer-review
91 Citations (Scopus) -
2009
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability
Densham, R. M., O'Neill, E., Munro, J., König, I., Anderson, K., Kolch, W. & Olson, M. F., Dec 2009, In: Molecular and Cellular Biology. 29, 24, p. 6380-90 11 p.Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus) -
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
Morris, J., Boutell, C., Keppler, M., Densham, R., Weekes, D., Alamshah, A., Butler, L., Galanty, Y., Pangon, L., Kiuchi, T., Ng, T. & Solomon, E., 17 Dec 2009, In: Nature. 462, 7275, p. 886-890 5 p.Research output: Contribution to journal › Article
312 Citations (Scopus) -
2008
ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover
Densham, R. M., Todd, D. E., Balmanno, K. & Cook, S. J., Nov 2008, In: Cellular Signalling. 20, 11, p. 1986-94 9 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
2006
Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton
Coleman, M. L., Densham, R. M., Croft, D. R. & Olson, M. F., 4 May 2006, In: Oncogene. 25, 19, p. 2708–2716Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
2004
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest
Todd, D. E., Densham, R. M., Molton, S. A., Balmanno, K., Newson, C., Weston, C. R., Garner, A. P., Scott, L. & Cook, S. J., 22 Apr 2004, In: Oncogene. 23, 19, p. 3284-95 12 p.Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus)