Research output per year
Research output per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Mathew Coleman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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5‑Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji‑C Domain-Containing Protein 5
Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, , 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder
Westrip, C. A. E., Paul, F., Al-Murshedi, F., Qaitoon, H., Cham, B., Fletcher, S. C., Hendrix, E., Boora, U., Ng, A. Y. J., Bonnard, C., Najafi, M., Alawbathani, S., Lambert, I., Fox, G., Venkatesh, B., Bertoli-Avella, A., Tan, E. S., Al-Maawali, A., Reversade, B. & Coleman, M. L., Sept 2023, In: Genetics in Medicine. 25, 9, 9 p., 100893.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Developmentally regulated GTPases: structure, function and roles in disease
Westrip, C. A. E., Zhuang, Q., Hall, C., Eaton, C. D. & Coleman, M. L., 19 Oct 2021, In: Cellular and Molecular Life Sciences. 78, 23, p. 7219-7235 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
First-in-class inhibitors of the ribosomal oxygenase MINA53
Nowak, R. P., Tumber, A., Hendrix, E., Ansari, M. S. Z., Sabatino, M., Antonini, L., Andrijes, R., Salah, E., Mautone, N., Pellegrini, F. R., Simelis, K., Kawamura, A., Johansson, C., Passeri, D., Pellicciari, R., Ciogli, A., Del Bufalo, D., Ragno, R., Coleman, M. L. & Trisciuoglio, D. & 4 others, , 9 Dec 2021, In: Journal of Medicinal Chemistry. 64, 23, p. 17031-17050 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Dissecting Hydroxylase Biology Implicated in Development Disorders and Cancer
Coleman, M. (Principal Investigator) & Smerdon, S. (Co-Investigator)
1/12/24 → 30/11/27
Project: Research Councils
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MRC IAA: Targeting translational termination to treat nonsense mutation driven disease
Beggs, A. (Co-Investigator) & Coleman, M. (Principal Investigator)
Medical Research Council, The Wellcome Trust
1/12/23 → 31/03/25
Project: Research
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Investigating the role of protein hydroxylation in cancer
Beggs, A. (Co-Investigator), Stewart, G. (Co-Investigator), Saponaro, M. (Co-Investigator), Higgs, M. (Co-Investigator) & Coleman, M. (Principal Investigator)
1/11/17 → 31/03/25
Project: Research
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ChondrOx 2.0 : Investigation of next-generation chondrosarcoma models and therapeutic strategies
Coleman, M. (Principal Investigator) & Fletcher, S. (Co-Investigator)
1/09/24 → 28/02/25
Project: Research
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Exploring new therapeutic opportunities based on replication stress and hydroxylase biology in next-generation chondrosarcoma models
Beggs, A. (Co-Investigator), Fletcher, S. (Co-Investigator) & Coleman, M. (Principal Investigator)
1/11/23 → 28/02/25
Project: Research