Projects per year
Search results
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Active
Thrombo-STOP: Apixaban thromboprophylaxis to prevent venous thromboembolism in ambulatory lung cancer patients undergoing systemic anticancer treatment
Jowett, S. (Co-Investigator), Billingham, L. (Co-Investigator), Ignatowicz, A. (Co-Investigator), Newnham, M. (Principal Investigator), Turner, A. (Co-Investigator), Pirrie, S. (Co-Investigator) & Middleton, G. (Co-Investigator)
1/03/25 → 28/02/30
Project: Other Government Departments
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CRUK CRCTU Core Funding
Fisher, B. (Co-Investigator), Billingham, L. (Researcher), Bach, S. (Researcher), Kearns, P. (Co-Investigator), Pratt, G. (Researcher), Bowden, S. (Principal Investigator), Rea, D. (Researcher), Middleton, G. (Co-Investigator) & Gates, S. (Researcher)
1/10/23 → 30/09/28
Project: Research
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Investigating Regulatory B cells as determinants of immune-related adverse events following checkpoint blockade therapy
Middleton, G. (Co-Investigator) & Patel, A. (Principal Investigator)
1/08/23 → 31/07/25
Project: Research
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KETO-LUNG
Billingham, L. (Co-Investigator), Tennant, D. (Co-Investigator), Savage, J. (Co-Investigator), Middleton, G. (Principal Investigator) & Fletcher, P. (Researcher)
1/06/23 → 31/05/26
Project: Research
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Birmingham Clinical Academic Training Programme 2023 Year 5
Middleton, G. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research
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Experimental Cancer Medicine Centre - 2023
Middleton, G. (Principal Investigator) & Beggs, A. (Co-Investigator)
1/04/23 → 31/03/28
Project: Research
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ORB-AZ: Organoid Research Birmingham-AZ
Middleton, G. (Co-Investigator), Gendoo, D. (Co-Investigator), Patel, P. (Co-Investigator), Lal, N. (Co-Investigator) & Beggs, A. (Principal Investigator)
1/08/22 → 31/07/26
Project: Industry
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The Birmingham CRUK Centre Clinical Academic Training and Research Programme Year 4
Middleton, G. (Principal Investigator), Harper, L. (Co-Investigator), Tennant, D. (Co-Investigator), Thomas, K. (Co-Investigator), Sundar, S. (Co-Investigator) & Brain, K. (Co-Investigator)
1/04/22 → 31/03/27
Project: Research
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Immunotherapeutic Targeting of Pancreatic Cancer
Contino, G. (Co-Investigator), Croft, W. (Researcher), Moss, P. (Principal Investigator), Middleton, G. (Researcher) & Pearce, H. (Co-Investigator)
9/09/21 → 31/03/25
Project: Industry
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The Birmingham CRUK Centre Clinical Academic Training and Research Programme Year 3
Thomas, K. (Co-Investigator), Middleton, G. (Principal Investigator), Harper, L. (Co-Investigator), Tennant, D. (Co-Investigator), Brain, K. (Co-Investigator) & Sundar, S. (Co-Investigator)
1/06/21 → 31/05/27
Project: Research
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The Birmingham CRUK Centre Clinical Academic Training and Research Programme Year 2
Thomas, K. (Co-Investigator), Harper, L. (Co-Investigator), Sundar, S. (Co-Investigator), Brain, K. (Co-Investigator), Middleton, G. (Principal Investigator) & Tennant, D. (Co-Investigator)
1/09/20 → 31/08/26
Project: Research
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H2020_IMI2-RIA_IMMUCAN_PARTNER
Beggs, A. (Co-Investigator) & Middleton, G. (Principal Investigator)
31/03/19 → 30/06/26
Project: EU
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ANICCA-Class II : A phase II Trial of nivolumab in strong class II expressing microsatellite stable colorectal cancer patients (MSS CRC)
Billingham, L. (Co-Investigator) & Middleton, G. (Principal Investigator)
BRISTOL MYERS SQUIBB PHARMACEUTICALS
1/01/18 → 31/12/25
Project: Industry
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National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer
Billingham, L. (Co-Investigator), Steven, N. (Co-Investigator) & Middleton, G. (Principal Investigator)
1/10/16 → 30/04/25
Project: Research
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Finished
Defining the nature of the myeloid contexture according to metastatic site in colorectal cancer
Middleton, G. (Principal Investigator)
7/03/22 → 31/03/23
Project: Research
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MHC Class II expression in MSS (non-MHC Class II inducible) colorectal cancer
Middleton, G. (Co-Investigator) & Beggs, A. (Principal Investigator)
CANCER RESEARCH TECHNOLOGY LTD
1/05/21 → 9/09/22
Project: Industry
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The Identification of Novel Therapy Options in Difficult to Treat Non-Small Cell Lung Cancer (INTO-Lung Cancer)
Middleton, G. (Principal Investigator) & Beggs, A. (Co-Investigator)
1/10/20 → 30/09/23
Project: Research
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Functional genomics of aneuploidy in Oesophageal Adenocarcinoma
Middleton, G. (Co-Investigator), Contino, G. (Principal Investigator) & Beggs, A. (Co-Investigator)
1/09/20 → 31/08/24
Project: Research
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CATALYST: A randomised early phase adaptive trial for new drugs for SARS-CoV-2+ patients
Gates, S. (Co-Investigator), Parekh, D. (Co-Investigator), Bowden, S. (Co-Investigator), Kearns, P. (Principal Investigator), Bion, J. (Co-Investigator), Slade, D. (Co-Investigator), Middleton, G. (Co-Investigator), Patel, J. (Co-Investigator), Thickett, D. (Co-Investigator), Fisher, B. (Co-Investigator), Newsome, P. (Researcher), Gao Smith, F. (Co-Investigator), Rowe, A. (Co-Investigator), Sharpe, R. (Co-Investigator), Mussai, F. (Co-Investigator) & Sapey, E. (Co-Investigator)
1/06/20 → 31/05/21
Project: Research Councils
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A phase II trial to assess the activity of Gemtuzumab Ozogamicin Therapy in HAemophagocytic lymphohistiocytosis (HLH) or Macrophage activation syndrome (MAS) or relapsed/refractory solid tumours
De Santo, C. (Co-Investigator), Kearns, P. (Co-Investigator), Billingham, L. (Co-Investigator), Middleton, G. (Principal Investigator) & Mussai, F. (Co-Investigator)
Little Princess Trust, Eveson Charitable Trust
1/01/20 → 31/12/24
Project: Research
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Identification of genetic factors that predispose to either immune checkpoint inhibitor or conventional chemotherapy toxicity
Palles, C. (Principal Investigator), Middleton, G. (Co-Investigator) & Steven, N. (Co-Investigator)
1/10/19 → 31/12/24
Project: Research
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The Birmingham CRUK Centre Clinical Academic Training Programme
Middleton, G. (Principal Investigator), Brain, K. (Co-Investigator), Thomas, K. (Co-Investigator), Sundar, S. (Co-Investigator), Harper, L. (Co-Investigator) & Tennant, D. (Co-Investigator)
1/10/19 → 31/12/24
Project: Research
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BHP Starter Fellowship - Toritseju Sillo
Middleton, G. (Principal Investigator)
1/10/19 → 30/09/20
Project: Research
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IMMUNE GENE EXPRESSION AND NEOANTIGEN CLONALITY IN COLORECTAL CANCER
Yau, C. (Co-Investigator), Beggs, A. (Co-Investigator) & Middleton, G. (Principal Investigator)
BOWEL DISEASE RESEARCH FOUNDATION
29/04/19 → 29/04/21
Project: Research
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Is B cell Immune phenotype predictive of outcome and toxicity with combination checkpoint blockade in Non-small cell lung cancer patients
Patel, A. (Principal Investigator) & Middleton, G. (Co-Investigator)
1/02/19 → 31/01/21
Project: Research
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Tracer X - Fellowship
Naidu, B. (Principal Investigator) & Middleton, G. (Co-Investigator)
31/03/18 → 30/06/20
Project: Research
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Amendment for the National Lung Matrix Trial: Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer
Steven, N. (Co-Investigator), Middleton, G. (Principal Investigator) & Billingham, L. (Co-Investigator)
1/10/17 → 31/03/19
Project: Research
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Clinical Training Award Cycle 3 2017
Middleton, G. (Principal Investigator)
1/09/17 → 31/12/22
Project: Research
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Understanding the molecular basis and consequences of chemoradiosensitivity in rectal cancer in order to improve tharapy (MOL-RSRC)
Middleton, G. (Co-Investigator), Cazier, J.-B. (Co-Investigator) & Beggs, A. (Principal Investigator)
3/04/17 → 31/03/22
Project: Research
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Birmingham ECMC
Beggs, A. (Co-Investigator), Moss, P. (Co-Investigator), Kearns, P. (Co-Investigator), Craddock, C. (Co-Investigator), Nankivell, P. (Co-Investigator), Willcox, B. (Co-Investigator), Morton, D. (Co-Investigator), Middleton, G. (Principal Investigator), Khoja, L. (Researcher), Drayson, M. (Co-Investigator), Tomlinson, I. (Co-Investigator), Steven, N. (Co-Investigator), Taylor, M. (Co-Investigator), Watts, C. (Co-Investigator) & Mehanna, H. (Co-Investigator)
1/04/17 → 31/03/23
Project: Research
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Cancer Research UK Birmingham Centre. See Also RCPV20624
Kearns, P. (Co-Investigator), Willcox, B. (Principal Investigator), Lee, S. (Co-Investigator), Middleton, G. (Co-Investigator), Moss, P. (Co-Investigator) & Morton, D. (Co-Investigator)
1/04/17 → 31/12/24
Project: Research
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Study the mechanisms in BRAF mutant colorectal cancer (CRC) cells treated with PLX8394
Middleton, G. (Principal Investigator)
25/08/16 → 30/09/23
Project: Research
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A comparison of the immunological microenvironment of primary and pulmonary metastic colorectal cancer.
Willcox, B. (Principal Investigator) & Middleton, G. (Co-Investigator)
1/07/16 → 31/10/17
Project: Research
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From immune suppression to immunotherapy: the function and clinical significance of the immune response to pancreatic cancer
Moss, P. (Principal Investigator), Middleton, G. (Co-Investigator) & Cazier, J.-B. (Co-Investigator)
1/07/16 → 31/01/23
Project: Research
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Understanding the cells that supress the immune system in patients with malignant pleural mesothelioma and investigating treatments to target these cells
Middleton, G. (Principal Investigator)
1/04/16 → 31/12/19
Project: Research
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RUXSAC -A double blind, placebo-controlled, randomized phase II study of Pemetrexed and Cisplatin with and without Ruxolitinib in Malignant Pleural Mesothelioma.
De Santo, C. (Co-Investigator), Billingham, L. (Co-Investigator), Mussai, F. (Co-Investigator) & Middleton, G. (Principal Investigator)
NOVARTIS PHARMACEUTICALS UK LTD, NIHR
17/12/15 → 31/12/20
Project: Research
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A phase II trial of MK-3475 in patients with non-small cell lung cancer with a performance status of 2 (PePS2)
Billingham, L. (Co-Investigator) & Middleton, G. (Principal Investigator)
21/10/15 → 31/12/24
Project: Industry
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Understanding the role of myeloid derived suppressor cells (MDSCs) in the immune microenvironment of malignant pleural mesothelioma an targeting the effects of clinical JAK2/STAT3 inhibition on their number and function
Middleton, G. (Principal Investigator)
THE JUNE HANCOCK MESOTHELIOMA RESEARCH FUND
1/03/15 → 28/02/18
Project: Research
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Stratified Medicene Matrix Trial
Middleton, G. (Principal Investigator), Billingham, L. (Co-Investigator) & Steven, N. (Co-Investigator)
Cancer Research Uk, INIVATA LTD, ASTRA ZENECA UK LIMITED
1/08/14 → 31/10/21
Project: Research
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Stratified Medicine:Methods for Evaluating Predictive Biomarkers for Treatment of Cancer
Billingham, L. (Principal Investigator), Deeks, J. (Co-Investigator), Riley, R. (Co-Investigator), Craddock, C. (Co-Investigator), Middleton, G. (Co-Investigator) & Morton, D. (Co-Investigator)
1/06/14 → 31/05/17
Project: Research
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Tracking Cancer Evolution through Therapy (Tracer X)
Middleton, G. (Principal Investigator) & Naidu, B. (Co-Investigator)
1/01/14 → 31/12/22
Project: Research
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Quantification and functional consequences of TTN mutations in human colorectal cancer
Middleton, G. (Principal Investigator)
1/07/13 → 31/03/14
Project: Research
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Molecular selection of therapy in metastatic colorectal cancer: a molecularly stratified randomised controlled trial programme (FOCUS 4)
Middleton, G. (Principal Investigator)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/04/13 → 31/03/20
Project: Other Government Departments
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(60MTHS)Renewal of ECMC at Birmingham
Tselepis, C. (Co-Investigator), Middleton, G. (Co-Investigator), Craddock, C. (Co-Investigator), Moss, P. (Co-Investigator), Steven, N. (Co-Investigator) & Morton, D. (Principal Investigator)
1/04/12 → 31/03/17
Project: Research