Research output per year
Research output per year
Personal profile
Biography
Dr Brain graduated with a PhD in Physiology in 1998 and in Medicine in 1999 from the University of Sydney, Australia. After working as a medical officer at the Royal Prince Alfred Hospital in Sydney he joined the Department of Pharmacology, Oxford, in 2001.
While in Oxford, Dr Brain held a series of research fellowships, including a Nuffield Medical Fellowship, Wellcome Trust Career Development Research Fellowship (both based in the Department of Pharmacology), Staines Medical Research Fellowship (Exeter College) and the post of Research Fellow and Tutor (Keble College). In 2009 he moved to the post of Senior Lecturer (Neuropharmacology) at the University of Birmingham. His field of research is Autonomic Neuroscience (he is the International Secretary for the International Society for Autonomic Neuroscience), is the Head of Intercalation for the College of Medical and Dental Sciences, and the deputy lead for Years 1 and 2 of the MBChB programme. He also teaches in the fields of Pharmacology and Renal physiology.
Research interests
Research interests
Dr Brain’s laboratory aims to understand autonomic junctional transmission from fundamental principles through to therapeutic interventions
Current projects
• The effect of cannabinoids on sympathetic transmission
• The role of parasympathetic transmission in bladder overactivity (with R. Manchanda, IIT, Mumbai)
• Developing new optical and MRI-sensitive probes for sympathetic failure (with S. Muzerengi)
Qualifications
Senior Lecturer:
• Fellow of the British Pharmacological Society (2015)
• MA, University of Oxford, 2002
• MB/BS (Hons), University of Sydney, 2000
• PhD (Physiology), University of Sydney, 1999
• BSc(Med)(Hons), University of Sydney, 1995
• BSc (Physics and Pure Mathematics), University of Sydney, 1995
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bachelor of Medicine and Bachelor of Surgery, MB/BS
Award Date: 1 Jan 2000
Doctor of Philosophy, Calcium in autonomic neurons following action potentials, University of Sydney
Award Date: 1 Jan 1999
Keywords
- RM Therapeutics. Pharmacology
- QP Physiology
- Autonomic Nervous System
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Analysis of the electrical activity in detrusor smooth muscle: inferences on syncytial function
Padmakumar, M., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. Appukuttan, S. & Manchanda, R. (eds.). 1 ed. New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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A novel, enhanced model for the detrusor syncytium: incorporating innervated bundles
Sengupta, N., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. Manchanda, R. & Appukuttan, S. (eds.). New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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Biophysically Realistic Modles of Detrusor Ion Channels: role in shaping spike and excitavility
Mahapatra, C., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. 1 ed. New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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High-resolution ex-vivo structural and functional analysis of sympathetic innervation using a novel confocal fluorescence technique
Briggs, D., Hunt, J., Raut, S., Saleeb-Mousa, J., Coney, A., Kalla, M., Holmes, A. & Brain, K., 25 Jul 2024, p. 177-177. 1 p.Research output: Contribution to conference (unpublished) › Abstract
Open AccessFile80 Downloads (Pure) -
A modified Angoff B screening method for collusion detection in examinations delivered on the MSCAA and Speedwell platforms
Brain, K. & Nagy, Z., 19 Oct 2023, In: The Clinical Teacher. 20, S1, p. 85-86 2 p.Research output: Contribution to journal › Abstract › peer-review
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Inflammatory signalling in the left atrium, noradrenaline transporter and atrial fibrillation in animal models of obstructive sleep apnoea [Sub-award of 1001749]
Coney, A. (Co-Investigator), Holmes, A. (Principal Investigator) & Brain, K. (Co-Investigator)
KENNEDY TRUST FOR RHEUMATOLOGY RESEARCH
1/06/22 → 31/05/25
Project: Research
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MB PhD studentships
Raza, K. (Principal Investigator), Newsome, P. (Co-Investigator), Thomas, K. (Co-Investigator), Jones, S. (Co-Investigator), Sapey, E. (Co-Investigator), Nirantharakumar, K. (Co-Investigator), Tennant, D. (Co-Investigator), Lord, J. (Co-Investigator), Brain, K. (Co-Investigator) & Harper, L. (Co-Investigator)
KENNEDY TRUST FOR RHEUMATOLOGY RESEARCH
1/02/21 → 31/12/28
Project: Research
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The Birmingham CRUK Centre Clinical Academic Training Programme
Middleton, G. (Principal Investigator), Brain, K. (Co-Investigator), Thomas, K. (Co-Investigator), Sundar, S. (Co-Investigator), Harper, L. (Co-Investigator) & Tennant, D. (Co-Investigator)
1/04/19 → 31/03/27
Project: Research
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Development of a 19F based MRI probe for labelling dopaminergic neurons in Parkinson’s disease
Brain, K. (Co-Investigator) & Muzerengi, S. (Principal Investigator)
University Hospital Birmingham Nhs Foundation Trust
1/02/20 → 27/10/21
Project: Research
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Developing new, fluorescence-based techniques to study sympathetic nerve function within blood vessels and the heart
Brain, K. (Principal Investigator), Marshall, J. (Co-Investigator) & Fabritz, L. (Co-Investigator)
26/09/17 → 30/12/20
Project: Research
Activities
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Review of Intercalation programmes
Brain, K. (Advisor)
25 Apr 2022Activity: Consultancy, CPD, training and secondments › Consultancy
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Keynote address and MBChB admission talk
Brain, K. (Chair)
28 Feb 2020Activity: Academic and Industrial events › Guest lecture or Invited talk