Optical mapping design for murine atrial electrophysiology
Research output: Contribution to journal › Article › peer-review
Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.
|Number of pages||9|
|Journal||Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization|
|Early online date||15 Nov 2015|
|Publication status||E-pub ahead of print - 15 Nov 2015|
- optical mapping , cardiovascular disease , voltage imaging , electrophysiology , action potential