Optical mapping design for murine atrial electrophysiology

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Abstract

Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.
Original languageEnglish
Pages (from-to)368-376
Number of pages9
JournalComputer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization
Volume5
Issue number5
Early online date15 Nov 2015
DOIs
Publication statusE-pub ahead of print - 15 Nov 2015

Keywords

  • optical mapping
  • cardiovascular disease
  • voltage imaging
  • electrophysiology
  • action potential

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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