Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth

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  Pharmaceutical targeting of RAS in Acute Myeloid Leukaemia with RAS mutations or FLT3-ITD

  Coleman, D. (Principal Investigator)

  LEUKAEMIA UK

  1/01/22 → 29/02/24

  Project: Research

  • Myeloid 100%
  • Gene Regulatory Network 95%
  • Acute Myeloid Leukemia 87%
  • Activator protein-1 (AP-1) 62%
  • Runt-related Transcription Factor 1 (RUNX1) 57%

• The role of RUNX1 and the AP-1 transcription factor family in t(8;21) AML

  Cockerill, P. (Co-Investigator) & Bonifer, C. (Principal Investigator)

  BLOODWISE

  1/10/20 → 31/12/23

  Project: Research

  • Myeloid 100%
  • Acute Myeloid Leukemia 58%
  • Gene Regulatory Network 41%
  • CCAAT Enhancer Binding Protein Alpha 33%
  • Stem Cell 33%

• Finding therapeutic targets in FLT3-ITD AML using a systems biology approach

  Cockerill, P. (Co-Investigator) & Bonifer, C. (Principal Investigator)

  Medical Research Council

  1/09/19 → 31/12/23

  Project: Research Councils

  • RUNX1 100%
  • Myeloid 93%
  • Gene Regulatory Network 87%
  • Acute Myeloid Leukemia 81%
  • Transcription Factors 78%