Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth

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  Pharmaceutical targeting of RAS in Acute Myeloid Leukaemia with RAS mutations or FLT3-ITD

  Coleman, D.

  LEUKAEMIA UK

  1/01/22 → 29/02/24

  Project: Research

  • Gene Regulatory Networks 100%
  • Acute Myeloid Leukemia 80%
  • Transcription Factor AP-1 66%
  • stem cells 66%
  • Growth 64%

• The role of RUNX1 and the AP-1 transcription factor family in t(8;21) AML

  Cockerill, P. & Bonifer, C.

  BLOODWISE

  1/10/20 → 31/12/23

  Project: Research

  • Acute Myeloid Leukemia 100%
  • Gene Regulatory Networks 62%
  • stem cells 52%
  • leukemias 41%
  • Cell Lineage 40%

• Finding therapeutic targets in FLT3-ITD AML using a systems biology approach

  Cockerill, P. & Bonifer, C.

  Medical Research Council

  1/09/19 → 31/12/23

  Project: Research Councils

  • Gene Regulatory Networks 100%
  • Acute Myeloid Leukemia 95%
  • Chromatin 62%
  • Transcription Factors 56%
  • Mutation 42%