Research output per year
Research output per year
- 32 results
Search results
-
2026
Functional importance of Asp264 in the ketosynthase domain of Pks13 in Mycobacterium smegmatis
Modak, M., Ghadbane, H., Futterer, K., Bhatt, A. & Besra, G. S., Dec 2026, In: The Cell Surface. 16, 11 p., 100178.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Mechanism of the M. tuberculosis DprE1–DprE2 epimerase complex and inhibition by anti-tubercular drugs
Gao, S., Wu, F., Zhang, Y., Batt, S. M., Wei, C., Wang, Z., Yang, X., Abrahams, K. A., Fütterer, K., Liu, X., Wang, P., Besra, G. S., Rao, Z. & Zhang, L., 2 Sept 2026, (E-pub ahead of print) In: Nature Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Downloads (Pure) -
2025
Exploration of vanoxerine analogues as antibacterial agents
Kingdon, A. D. H., Adcock, H. V., Kasimati, E.-M., Craven, P., van Schaik, W., Cox, L. R. & Besra, G. S., Jan 2025, In: The Journal of antibiotics. 78, 1, p. 54-63 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
Relating corynebacterial cell envelope layers to its biochemical and physical properties
Modak, M., Waturuocha, U. W., Saini, D. K., Bhatt, A. & Besra, G. S., Dec 2025, In: The Cell Surface. 14, 9 p., 100162.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
The deacetylase NagA mediates the remodelling and recycling of peptidoglycan derived amino sugars in mycobacteria
Guy, C. S., Cooper, C., Karlikowska, M., Harrison, J., Singh, A., Servín-González, L. S., Evans, C. A., Bakker, S. E., Bottrill, A., Bhatt, A., Mesnage, S., Besra, G. S. & Fullam, E., 14 Aug 2025, (E-pub ahead of print) In: The Journal of biological chemistry. 110597.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis
Singh, M., Batt, S. M., Canales, C. S. C., Pavan, F. R., Kumar, S. A., Akshatha, H. S., Bhagyalalitha, M., Pujar, K. G., Bidye, D., Pujar, G. V. & Besra, G. S., 31 Dec 2024, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 39, 1, 16 p., 2403744.Research output: Contribution to journal › Article › peer-review
Open AccessFile260 Downloads (Pure) -
Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Gao, S., Wu, F., Gurcha, S. S., Batt, S. M., Besra, G. S., Rao, Z. & Zhang, L., 15 Mar 2024, (E-pub ahead of print) In: Nature Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile88 Downloads (Pure) -
The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth
Franklin, A., Salgueiro, V. C., Layton, A. J., Sullivan, R., Mize, T., Vázquez-Iniesta, L., Benedict, S. T., Gurcha, S. S., Anso, I., Besra, G. S., Banzhaf, M., Lovering, A. L., Williams, S. J., Guerin, M. E., Scott, N. E., Prados-Rosales, R., Lowe, E. C. & Moynihan, P. J., 9 Jul 2024, In: Nature Communications. 15, 1, 5740.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
The role of ABC transporter DrrABC in the export of PDIM in Mycobacterium tuberculosis
Moolla, N., Weaver, H., Bailo, R., Singh, A., Bavro, V. N. & Bhatt, A., Dec 2024, In: The Cell Surface. 12, 10 p., 100132.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
Top five unanswered questions in bacterial cell wall research
Batt, S. M., Abrahams, K. A. & Besra, G. S., Jun 2024, In: The Cell Surface. 11, 4 p., 100122.Research output: Contribution to journal › Review article › peer-review
Open AccessFile118 Downloads (Pure) -
2023
Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
Batt, S. M., Toth, S., Rodriguez, B., Abrahams, K. A., Veerapen, N., Chiodarelli, G., Cox, L. R., Moynihan, P. J., Lelievre, J., Fütterer, K. & Besra, G. S., 23 Jan 2023, In: Microbiology. 169, 1, 001288.Research output: Contribution to journal › Article › peer-review
Open AccessFile242 Downloads (Pure) -
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Abrahams, K. A., Batt, S. M., Gurcha, S. S., Veerapen, N., Bashiri, G. & Besra, G. S., 28 Jun 2023, In: Nature Communications. 14, 1, 10 p., 3828.Research output: Contribution to journal › Article › peer-review
Open AccessFile223 Downloads (Pure) -
Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers
Lee, O.Y.-C., Wu, H. H. T. & Besra, G. S., Dec 2023, In: Tuberculosis. 143, Supplement, 6 p., 102415.Research output: Contribution to journal › Review article › peer-review
Open AccessFile141 Downloads (Pure) -
Sensitive lipid biomarker detection for tuberculosis in late Neanderthal skeletons from Subalyuk Cave, Hungary
Lee, O.Y.-C., Wu, H. H. T., Besra, G. S., Minnikin, D. E., Jaeger, H. Y., Maixner, F., Zink, A., Gasparik, M., Pap, I., Bereczki, Z. & Pálfi, G., Dec 2023, In: Tuberculosis. 143, Supplement, 8 p., 102420.Research output: Contribution to journal › Review article › peer-review
Open AccessFile165 Downloads (Pure) -
2022
The mycobacterial desaturase DesA2 is associated with mycolic acid biosynthesis
Bailo, R., Radhakrishnan, A., Singh, A., Nakaya, M., Fujiwara, N. & Bhatt, A., 28 Apr 2022, In: Scientific Reports. 12, 1, 6943.Research output: Contribution to journal › Article › peer-review
Open AccessFile109 Downloads (Pure) -
The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis
Moorey, A. R. & Besra, G. S., Dec 2022, In: The Cell Surface. 8, 4 p., 100083.Research output: Contribution to journal › Review article › peer-review
Open AccessFile39 Downloads (Pure) -
2021
Bioink formulations for bone tissue regeneration
Li, N., Guo, R. & Zhang, J., 5 Feb 2021, In: Frontiers in Bioengineering and Biotechnology. 9, 630488.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)331 Downloads (Pure) -
Chemical insights into the search for MAIT cells activators
Veerapen, N., Hobrath, J., Besra, A. K. & Besra, G. S., Jan 2021, In: Molecular immunology. 129, p. 114-120 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile281 Downloads (Pure) -
Discovery of novel thiophene-arylamide derivatives as DprE1 inhibitors with potent antimycobacterial activities
Wang, P., Batt, S. M., Wang, B., Fu, L., Qin, R., Lu, Y., Li, G., Besra, G. S. & Huang, H., 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 6241-6261 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile486 Downloads (Pure) -
Mycobacterium abscessus biofilms produce an extracellular matrix and have a distinct mycolic acid profile
Dokic, A., Peterson, E., Arrieta-Ortiz, M. L., Pan, M., Di Maio, A., Baliga, N. & Bhatt, A., Dec 2021, In: The Cell Surface. 7, 100051.Research output: Contribution to journal › Article › peer-review
Open AccessFile427 Downloads (Pure) -
Structure-function analysis of MmpL7-mediated lipid transport in mycobacteria
Moolla, N., Bailo, R., Marshall, R., Bavro, V. N. & Bhatt, A., Dec 2021, In: The Cell Surface. 7, 100062.Research output: Contribution to journal › Article › peer-review
Open AccessFile144 Downloads (Pure) -
Synthesis and recycling of the mycobacterial cell envelope
Abrahams, K. A. & Besra, G. S., Apr 2021, In: Current Opinion in Microbiology. 60, p. 58-65 8 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile416 Downloads (Pure) -
The multi-target aspect of an MmpL3 inhibitor: the BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
Moorey, A. R., Cabanillas, A., Batt, S. M., Ghidelli-Disse, S., Urones, B., Sanz, O., Lelievre, J., Bantscheff, M., Cox, L. R. & Besra, G. S., Dec 2021, In: The Cell Surface. 7, 12 p., 100068.Research output: Contribution to journal › Article › peer-review
Open AccessFile211 Downloads (Pure) -
2020
Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall
Batt, S. M., Burke, C. E., Moorey, A. R. & Besra, G. S., Dec 2020, In: The Cell Surface. 6, 100044.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)419 Downloads (Pure) -
Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183
Abrahams, K. A., Hu, W., Lu, Y., Richardson, E. J., Loman, N. J., Huang, H., Besra, G. S. & Gang, L., Dec 2020, In: The Cell Surface. 6, 9 p., 100040.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)213 Downloads (Pure) -
Biofilms of the non-tuberculous Mycobacterium chelonae form an extracellular matrix and display distinct expression patterns
Vega-Dominguez, P., Peterson, E., Pan, M., Di Maio, A., Singh, S., Umapathy, S., Saini, D. K., Baliga, N. & Bhatt, A., Dec 2020, In: The Cell Surface. 6, 100043.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)264 Downloads (Pure) -
Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline
Burke, C., Jankute, M., Moynihan, P., Gonzalez Del Rio, R., Li, X., Esquivias, J., Lelièvre, J., Cox, J. A. G., Sacchettini, J. & Besra, G. S., 16 Oct 2020, In: FASEB BioAdvances. 2, 10, p. 600-612 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile311 Downloads (Pure) -
Mycobacterial drug discovery
Abrahams, K. A. & Besra, G. S., 1 Dec 2020, In: RSC Medicinal Chemistry. 11, 12, p. 1354-1365Research output: Contribution to journal › Article › peer-review
Open AccessFile266 Downloads (Pure) -
Probing fibronectin adsorption on chemically defined surfaces by means of single molecule force microscopy
Liamas, E., Black, R. A., Mulheran, P. A., Tampé, R., Wieneke, R., Thomas, O. R. T. & Zhang, Z. J., 24 Sept 2020, In: Scientific Reports. 10, 1, 15662.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)279 Downloads (Pure) -
The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system
Batt, S. M., Minnikin, D. E. & Besra, G. S., 29 May 2020, In: The Biochemical journal. 477, 10, p. 1983-2006 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)373 Downloads (Pure) -
Tuberculosis diagnostics: overcoming ancient challenges with modern solutions
MacGregor-Fairlie, M., Wilkinson, S., Besra, G. S. & Goldberg Oppenheimer, P., 1 Dec 2020, In: Emerging topics in life sciences. 4, 4, p. 423-436 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile264 Downloads (Pure) -
2019
The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow-growing mycobacteria
Javid, A., Cooper, C., Singh, A., Schindler, S., Hänisch, M., Marshall, R. L., Kalscheuer, R., Bavro, V. N. & Bhatt, A., 30 Nov 2019, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile243 Downloads (Pure)