The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

Sarah M Batt, David E Minnikin, Gurdyal S Besra

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
88 Downloads (Pure)

Abstract

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis.

Original languageEnglish
Pages (from-to)1983-2006
Number of pages24
JournalThe Biochemical journal
Volume477
Issue number10
DOIs
Publication statusPublished - 29 May 2020

Keywords

  • Cell Membranes
  • Excitation & Transport
  • Glycobiology
  • Microbiology
  • Molecular Interactions

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