Projects per year
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the leading cause of death from an infectious disease, with a mortality rate of over a million people per year. This pathogen's remarkable resilience and infectivity is largely due to its unique waxy cell envelope, 40% of which comprises complex lipids. Therefore, an understanding of the structure and function of the cell wall lipids is of huge indirect clinical significance. This review provides a synopsis of the cell envelope and the major lipids contained within, including structure, biosynthesis and roles in pathogenesis.
|Number of pages||24|
|Journal||The Biochemical journal|
|Publication status||Published - 29 May 2020|
Bibliographical note© 2020 The Author(s)
- Cell Membranes
- Excitation & Transport
- Molecular Interactions
FingerprintDive into the research topics of 'The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system'. Together they form a unique fingerprint.
The Mycobacterium tuberculosis Cell Envelope: unravelling complex cell wall assembly, degradation and re-cycling pathways
Besra, D., Bhatt, A., Futterer, K., Alderwick, L. & Zhang, J.
1/03/19 → 29/02/24
Project: Research Councils
An integrated multi-disciplinary approach to unravel complex and essential cell wall biosynthetic pathways
1/01/08 → 30/06/13