Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Oona Y-C Lee; Houdini H.T. Wu; Gurdyal S. Besra

doi:10.1016/j.tube.2023.102415

Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Oona Y-C Lee, Houdini H.T. Wu, Gurdyal S. Besra^*

^*Corresponding author for this work

Biosciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

Original language	English
Article number	102415
Number of pages	6
Journal	Tuberculosis
Volume	143
Issue number	Supplement
Early online date	25 Nov 2023
DOIs	https://doi.org/10.1016/j.tube.2023.102415
Publication status	Published - Dec 2023

Bibliographical note

Acknowledgements:
The authors would like to thank Professor György Pálfi (University of Szeged, Hungary) and his team for acknowledging David's contribution to the field over the years, as well as offering the opportunity to present this work in the memorial session at the third International Conference on the Evolution and Paleoepidemiology of tuberculosis (ICEPT) held in Szeged, Hungary in July 2022. These research projects were supported by the UK Medical Research Council (MR/S000542) and Leverhulme Trust (F/00094/BL).

Keywords

Mycobacterium tuberculosis
Cell envelope
Lipids
Mycolic acids
Cell wall

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tube.2023.102415Licence: Creative Commons: Attribution (CC BY)

LeeO2023ProfessorFinal published version, 5.55 MBLicence: Creative Commons: Attribution (CC BY)

1 Finished
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The Mycobacterium tuberculosis Cell Envelope: unravelling complex cell wall assembly, degradation and re-cycling pathways
Besra, D., Bhatt, A., Futterer, K., Alderwick, L. & Zhang, J.
Medical Research Council
1/03/19 → 28/02/25
Project: Research Councils
Lipid, sugar and protein biomarkers for ancient tuberculosis and leprosy
Besra, D., Minnikin, D., Cooper, H. & Viant, M.
Leverhulme Trust
1/01/11 → 30/09/14
Project: Research

Cite this

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title = "Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers",

abstract = "This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.",

keywords = "Mycobacterium tuberculosis, Cell envelope, Lipids, Mycolic acids, Cell wall",

author = "Lee, {Oona Y-C} and Wu, {Houdini H.T.} and Besra, {Gurdyal S.}",

note = "Acknowledgements: The authors would like to thank Professor Gy{\"o}rgy P{\'a}lfi (University of Szeged, Hungary) and his team for acknowledging David's contribution to the field over the years, as well as offering the opportunity to present this work in the memorial session at the third International Conference on the Evolution and Paleoepidemiology of tuberculosis (ICEPT) held in Szeged, Hungary in July 2022. These research projects were supported by the UK Medical Research Council (MR/S000542) and Leverhulme Trust (F/00094/BL).",

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doi = "10.1016/j.tube.2023.102415",

language = "English",

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journal = "Tuberculosis",

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T2 - An era of the mycobacterial cell wall lipid biomarkers

AU - Lee, Oona Y-C

AU - Wu, Houdini H.T.

AU - Besra, Gurdyal S.

N1 - Acknowledgements: The authors would like to thank Professor György Pálfi (University of Szeged, Hungary) and his team for acknowledging David's contribution to the field over the years, as well as offering the opportunity to present this work in the memorial session at the third International Conference on the Evolution and Paleoepidemiology of tuberculosis (ICEPT) held in Szeged, Hungary in July 2022. These research projects were supported by the UK Medical Research Council (MR/S000542) and Leverhulme Trust (F/00094/BL).

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N2 - This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

AB - This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

KW - Mycobacterium tuberculosis

KW - Cell envelope

KW - Lipids

KW - Mycolic acids

KW - Cell wall

U2 - 10.1016/j.tube.2023.102415

DO - 10.1016/j.tube.2023.102415

M3 - Review article

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JO - Tuberculosis

JF - Tuberculosis

IS - Supplement

M1 - 102415

ER -

Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

Abstract

Bibliographical note

Keywords

UN SDGs

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Projects

The Mycobacterium tuberculosis Cell Envelope: unravelling complex cell wall assembly, degradation and re-cycling pathways

Lipid, sugar and protein biomarkers for ancient tuberculosis and leprosy

Cite this