Projects per year
Abstract
This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.
Original language | English |
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Article number | 102415 |
Number of pages | 6 |
Journal | Tuberculosis |
Volume | 143 |
Issue number | Supplement |
Early online date | 25 Nov 2023 |
DOIs | |
Publication status | Published - Dec 2023 |
Bibliographical note
Acknowledgements:The authors would like to thank Professor György Pálfi (University of Szeged, Hungary) and his team for acknowledging David's contribution to the field over the years, as well as offering the opportunity to present this work in the memorial session at the third International Conference on the Evolution and Paleoepidemiology of tuberculosis (ICEPT) held in Szeged, Hungary in July 2022. These research projects were supported by the UK Medical Research Council (MR/S000542) and Leverhulme Trust (F/00094/BL).
Keywords
- Mycobacterium tuberculosis
- Cell envelope
- Lipids
- Mycolic acids
- Cell wall
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The Mycobacterium tuberculosis Cell Envelope: unravelling complex cell wall assembly, degradation and re-cycling pathways
Besra, D. (Principal Investigator), Bhatt, A. (Co-Investigator), Futterer, K. (Co-Investigator), Alderwick, L. (Co-Investigator) & Zhang, J. (Co-Investigator)
1/03/19 → 28/02/25
Project: Research Councils
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Lipid, sugar and protein biomarkers for ancient tuberculosis and leprosy
Besra, D. (Principal Investigator), Minnikin, D. (Co-Investigator), Cooper, H. (Co-Investigator) & Viant, M. (Co-Investigator)
1/01/11 → 30/09/14
Project: Research