Research output per year
Research output per year
Search results
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2023
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, , 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
Abu-Libdeh, B., Jhujh, S., Dhar, S., Sommers, J. A., Datta, A., Longo, G. M. C., Grange, L. J., Reynolds, J., Cooke, S., McNee, G., Hollingworth, R., Woodward, B., Ganesh, A. N., Smerdon, S., Nicolae, C. M., Durlacher-Bezer, K., Molho-Pessach, V., Abu-Libdeh, A., Meiner, V. & Moldovan, G.-L. & 4 others, , 1 Mar 2022, In: Journal of Clinical Investigation. 132, 5, e147301.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex
Von Morgen, P. V., Burdova, K., Flower, T. G., O'Reilly, N. J., Boulton, S. J., Smerdon, S. J., MacUrek, L. & Hoøejší, Z., 24 Aug 2017, In: Oncogene. 36, 34, p. 4943-4950 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Uncoupling conformational states from activity in an allosteric enzyme
Pisco, J. P., de Chiara, C., Pacholarz, K. J., Garza-Garcia, A., Ogrodowicz, R. W., Walker, P. A., Barran, P. E., Smerdon, S. J. & de Carvalho, L. P. S., 7 Aug 2017, In: Nature Communications. 8, 1, 10 p., 203.Research output: Contribution to journal › Article › peer-review
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2016
HF-free Boc synthesis of peptide thioesters for ligation and cyclization
Raz, R., Burlina, F., Ismail, M., Downward, J., Li, J., Smerdon, S. J., Quibell, M., White, P. D. & Offer, J., 10 Oct 2016, In: Angewandte Chemie (International Edition) . 55, 42, p. 13174-13179 6 p.Research output: Contribution to journal › Article › peer-review
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Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex
Kyrieleis, O. J. P., McIntosh, P. B., Webb, S. R., Calder, L. J., Lloyd, J., Patel, N. A., Martin, S. R., Robinson, C. V., Rosenthal, P. B. & Smerdon, S. J., 20 Dec 2016, In: Cell Reports. 17, 12, p. 3099-3106 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2015
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module
Martino, L., Pennell, S., Kelly, G., Busi, B., Brown, P., Atkinson, R. A., Salisbury, N. J. H., Ooi, Z.-H., See, K.-W., Smerdon, S. J., Alfano, C., Bui, T. T. T. & Conte, M. R., 9 Jan 2015, In: Nucleic Acids Research. 43, 1, p. 645-660 16 p.Research output: Contribution to journal › Article › peer-review
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Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains
Cherry, A. L., Nott, T. J., Kelly, G., Rulten, S. L., Caldecott, K. W. & Smerdon, S. J., Nov 2015, In: DNA Repair. 35, p. 116-125 10 p.Research output: Contribution to journal › Article › peer-review
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2014
A year in structural signaling: mTOR-the PIKK of the bunch?
Smerdon, S. J., 4 Mar 2014, In: Science signaling. 7, 315, pe6.Research output: Contribution to journal › Review article › peer-review
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FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain
Pennell, S., Déclais, A.-C., Li, J., Haire, L. F., Berg, W., Saldanha, J. W., Taylor, I. A., Rouse, J., Lilley, D. M. J. & Smerdon, S. J., 10 Jul 2014, In: Cell Reports. 8, 1, p. 84-93 10 p.Research output: Contribution to journal › Article › peer-review
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IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases
Ben-Addi, A., Mambole-Dema, A., Brender, C., Martin, S. R., Janzen, J., Kjaer, S., Smerdon, S. J. & Ley, S. C., 10 Jun 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. E2394-E2403 10 p.Research output: Contribution to journal › Article › peer-review
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Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex
Hořejší, Z., Stach, L., Flower, T. G., Joshi, D., Flynn, H., Skehel, J. M., O'Reilly, N. J., Ogrodowicz, R. W., Smerdon, S. J. & Boulton, S. J., 10 Apr 2014, In: Cell Reports. 7, 1, p. 19-26 8 p.Research output: Contribution to journal › Article › peer-review
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The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo, L. I., Fink, D., Rask, M.-B., Grøfte, M., Lukas, C., Nielsen, M. L., Smerdon, S. J., Lukas, J. & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Article › peer-review
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2013
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes
Rock, J. M., Lim, D., Stach, L., Ogrodowicz, R. W., Keck, J. M., Jones, M. H., Wong, C. C. L., Yates, J. R., Winey, M., Smerdon, S. J., Yaffe, M. B. & Amon, A., 17 May 2013, In: Science. 340, 6134, p. 871-875 5 p.Research output: Contribution to journal › Article › peer-review
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An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon
Spivey, V. L., Whalan, R. H., Hirst, E. M. A., Smerdon, S. J. & Buxton, R. S., 1 Oct 2013, In: FEMS Microbiology Letters. 347, 2, p. 107-115 9 p.Research output: Contribution to journal › Letter › peer-review
Open Access