Matthias Soller

Dr.

Accepting PhD Students

PhD projects

Matthias Soller’s primary research interest is how the information encoded in chromosomes instructs the building of the brain and allows an organism to perform elaborate tasks. His work focuses on post-transcriptionally controlled gene networks in neuronal development and function. Almost every gene is regulated at the post-transcriptional level in humans. Particularly important is the large number of genes that are alternatively spliced; and this type of gene regulation is most prevalently found in the brain. What are the functional consequences of this enormous increase in molecular diversity in neurons? How is alternative pre-mRNA processing co-ordinately regulated at a genomic level?

Dr Soller is using the fruit fly Drosophilawith its sophisticated genetic tools as a model to study alternative pre-mRNA processing. His favourite molecule to address how genes are co-ordinately regulated at the post-transcriptional level is the neuronal splicing regulator ELAV. The transcription factor EWG has been identified as a major target of ELAV. Through the analysis of EWG-regulated genes Dr Soller identified a prominent role of both ELAV and EWG in the regulation of structural plasticity at Drosophilasynapses.

1993 …2024

Research activity per year

Network

Jean-Yves Roignant

  • Universitätsmedizin Mainz
  • Institute of Molecular Biology (IMB), Mainz

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Jean-Marc Devaud

  • University of Toulouse

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Antonio Torres-Mendez

  • Centro de Regulacion Genomica, Barcelona

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Daniel Hess

  • Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
  • Robarts Research Institute
  • St. Michael's Hospital

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Osmar Malaspina

  • Universidade Estadual Paulista

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M Hollmann

  • University of Kassel

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Reinhard Stoger

  • University of Nottingham

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Tina Lence

  • Institute of Molecular Biology (IMB), Mainz

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H Reichert

  • University of Basel

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Dickon M. Humphrey

  • King’s College London

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Wing Hei Au

  • King’s College London

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K. White

  • Brandeis University

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Richard B. Parsons

  • King’s College London

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B Bello

  • University of Basel

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Bradley Smith

  • King’s College London

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Paraskevi Tziortzouda

  • King’s College London

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Youn-Bok Lee

  • King’s College London

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Yoshitsugu Adachi

  • King’s College London

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Alexandre David

  • University of Montpellier

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Rachel Hall

  • King’s College London

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Ane Martin-Anduaga

  • University of Leicester

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Thaisa Roat

  • Universidade Estadual Paulista

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Jonah Dearlove

  • King’s College London

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S Flister

  • University of Basel

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Daniel Hebenstreit

  • University of Warwick

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M.A. Schäfer

  • University of Kassel

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Jean-Marc Gallo

  • King’s College London

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Irmgard Haussmann

  • Birmingham City University

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Berndt Müller

  • University of Aberdeen

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Adel Boudi

  • King’s College London

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Jonathan Pettitt

  • University of Aberdeen

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Anjeet Rekhi

  • King’s College London

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Jessika C. Bridi

  • King’s College London

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Christopher E Shaw

  • King’s College London

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Greta Spinelli

  • King’s College London

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Danielle C. Diaper

  • King’s College London

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Claire Troakes

  • King’s College London

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Manolis Fanto

  • King’s College London

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Boris Rogelj

  • University of Ljubljana

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M. Müller

  • University of Basel

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Susanne Bornelöv

  • University of Cambridge

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Sarah Brivio

  • University of Aberdeen

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