Research output per year
Research output per year
Accepting PhD Students
PhD projects
Yun Fan’s research centres on understanding how cell death, cell proliferation and cell differentiation are co-ordinated to maintain tissue homeostasis. This has important implications for cancer development and tissue regeneration.
Tissue homeostasis in multicellular organisms requires co-ordinated cell death (apoptosis), cell proliferation and cell differentiation. Intriguingly, apoptotic cells can also induce additional divisions of the remaining cells to compensate for cell loss - a process termed apoptosis-induced compensatory cell proliferation (CP). Recent studies have revealed that stress-induced apoptotic cells can send growth signals to trigger CP through a non-apoptotic function of caspases, a family of cysteine-proteases that normally execute apoptosis. UsingDrosophila, Dr Fan’s lab has developed unique assays to systematically identify and characterise novel CP regulators in both proliferating and differentiating tissues. Its long-term goal is to elucidate the relevance of CP regulation in tissue regeneration and tumorigenesis.
Research activity per year
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Fan, Y. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/11/24 → 31/10/27
Project: Research Councils
Fan, Y. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
30/09/19 → 29/09/23
Project: Research Councils
Fan, Y. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/08/15 → 31/01/19
Project: Research Councils
Soller, M. (Principal Investigator) & Fan, Y. (Co-Investigator)
1/04/13 → 30/09/13
Project: Research