Twin Screw Granulation – A Literature Review

Research output: Contribution to journalArticlepeer-review

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Twin Screw Granulation – A Literature Review. / Chan Seem, Timothy; Rowson, Neil A.; Ingram, Andrew; Huang, Zhenyu; Yu, Shen; De Matas, Marcel; Gabbott, Ian; Reynolds, Gavin K.

In: Powder Technology, 07.02.2015.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Chan Seem, T., Rowson, N. A., Ingram, A., Huang, Z., Yu, S., De Matas, M., Gabbott, I., & Reynolds, G. K. (2015). Twin Screw Granulation – A Literature Review. Powder Technology. https://doi.org/10.1016/j.powtec.2015.01.075

Vancouver

Author

Chan Seem, Timothy ; Rowson, Neil A. ; Ingram, Andrew ; Huang, Zhenyu ; Yu, Shen ; De Matas, Marcel ; Gabbott, Ian ; Reynolds, Gavin K. / Twin Screw Granulation – A Literature Review. In: Powder Technology. 2015.

Bibtex

@article{4222bffbf9b54bf5b54df47ac1b79f03,
title = "Twin Screw Granulation – A Literature Review",
abstract = "This review article addresses the currently available literature on Twin Screw Granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry of the granulator over the formation of granules and the mechanisms of granulation are discussed. Process parameters including liquid to solid ratio, binder viscosity, method of binder addition, screw speed and material feed rate and their control of granule quality are analysed. The need for further understanding of granulation mechanisms and the interaction between screw elements is highlighted. As well as the difficulties in equating process parameters between different granulators to ensure product consistency across sites. TSG is a process with great potential for implementation into continuous processing lines but process understanding must be developed to ensure predictable consistent granule quality.",
keywords = "twin screw granulation, continuous processes, pharmaceutical technology, wet granulation",
author = "{Chan Seem}, Timothy and Rowson, {Neil A.} and Andrew Ingram and Zhenyu Huang and Shen Yu and {De Matas}, Marcel and Ian Gabbott and Reynolds, {Gavin K.}",
year = "2015",
month = feb,
day = "7",
doi = "10.1016/j.powtec.2015.01.075",
language = "English",
journal = "Powder Technology",
issn = "0032-5910",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Twin Screw Granulation – A Literature Review

AU - Chan Seem, Timothy

AU - Rowson, Neil A.

AU - Ingram, Andrew

AU - Huang, Zhenyu

AU - Yu, Shen

AU - De Matas, Marcel

AU - Gabbott, Ian

AU - Reynolds, Gavin K.

PY - 2015/2/7

Y1 - 2015/2/7

N2 - This review article addresses the currently available literature on Twin Screw Granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry of the granulator over the formation of granules and the mechanisms of granulation are discussed. Process parameters including liquid to solid ratio, binder viscosity, method of binder addition, screw speed and material feed rate and their control of granule quality are analysed. The need for further understanding of granulation mechanisms and the interaction between screw elements is highlighted. As well as the difficulties in equating process parameters between different granulators to ensure product consistency across sites. TSG is a process with great potential for implementation into continuous processing lines but process understanding must be developed to ensure predictable consistent granule quality.

AB - This review article addresses the currently available literature on Twin Screw Granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry of the granulator over the formation of granules and the mechanisms of granulation are discussed. Process parameters including liquid to solid ratio, binder viscosity, method of binder addition, screw speed and material feed rate and their control of granule quality are analysed. The need for further understanding of granulation mechanisms and the interaction between screw elements is highlighted. As well as the difficulties in equating process parameters between different granulators to ensure product consistency across sites. TSG is a process with great potential for implementation into continuous processing lines but process understanding must be developed to ensure predictable consistent granule quality.

KW - twin screw granulation

KW - continuous processes

KW - pharmaceutical technology

KW - wet granulation

U2 - 10.1016/j.powtec.2015.01.075

DO - 10.1016/j.powtec.2015.01.075

M3 - Article

JO - Powder Technology

JF - Powder Technology

SN - 0032-5910

ER -