Immobilisation of proteins by atomic clusters on surfaces
Research output: Contribution to journal › Review article
Authors
Colleges, School and Institutes
Abstract
In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (
Details
Original language | English |
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Pages (from-to) | 48-55 |
Number of pages | 8 |
Journal | Trends in Biotechnology |
Volume | 25 |
Publication status | Published - 1 Feb 2007 |