Immobilisation of proteins by atomic clusters on surfaces

Richard Palmer; Carl Leung

doi:10.1016/j.tibtech.2006.12.004

Immobilisation of proteins by atomic clusters on surfaces

Richard Palmer, Carl Leung

Physics and Astronomy

Research output: Contribution to journal › Review article

31 Citations (Scopus)

Abstract

In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (

Original language	English
Pages (from-to)	48-55
Number of pages	8
Journal	Trends in Biotechnology
Volume	25
DOIs	https://doi.org/10.1016/j.tibtech.2006.12.004
Publication status	Published - 1 Feb 2007

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10.1016/j.tibtech.2006.12.004

PLATFORM: Nanostructured Surfaces
Palmer, R. (Principal Investigator), Guo, Q. (Co-Investigator), Harrison, R. (Co-Investigator), Heath, J. (Co-Investigator), Jones, I. (Co-Investigator), Li, Z. (Co-Investigator), Moss, P. (Co-Investigator) & Robinson, A. (Co-Investigator)
Engineering & Physical Science Research Council
1/12/02 → 31/05/07
Project: Research Councils

Cite this

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DO - 10.1016/j.tibtech.2006.12.004

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Immobilisation of proteins by atomic clusters on surfaces

Abstract

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PLATFORM: Nanostructured Surfaces

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