Immobilisation of proteins by atomic clusters on surfaces

Richard Palmer, Carl Leung

Research output: Contribution to journalReview article

31 Citations (Scopus)


In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (
Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalTrends in Biotechnology
Publication statusPublished - 1 Feb 2007


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