DNA repair pathways as targets for cancer therapy

T Helleday; Eva Petermann; C Lundin; B Hodgson; RA Sharma

doi:10.1038/nrc2342

DNA repair pathways as targets for cancer therapy

T Helleday, Eva Petermann, C Lundin, B Hodgson, RA Sharma

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

1083 Citations (Scopus)

4594 Downloads (Pure)

Abstract

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

Original language	English
Pages (from-to)	193-204
Number of pages	12
Journal	Nature Reviews Cancer
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/nrc2342
Publication status	Published - 1 Mar 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nrc2342

Helleday_2008_NatureReviewsCancer
The definitive, peer-reviewed and edited version of this article is published in Nature Reviews Science, volume 8, issue 3, 2008 [http://dx.doi.org/10.1038/nrc2342]"
Submitted manuscript, 908 KBLicence: None: All rights reserved

Cite this

@article{cd4a5221f187476bb3ca5dc29d73a684,

title = "DNA repair pathways as targets for cancer therapy",

abstract = "DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.",

author = "T Helleday and Eva Petermann and C Lundin and B Hodgson and RA Sharma",

year = "2008",

month = mar,

day = "1",

doi = "10.1038/nrc2342",

language = "English",

volume = "8",

pages = "193--204",

journal = "Nature Reviews Cancer",

issn = "1474-1768",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - DNA repair pathways as targets for cancer therapy

AU - Helleday, T

AU - Petermann, Eva

AU - Lundin, C

AU - Hodgson, B

AU - Sharma, RA

PY - 2008/3/1

Y1 - 2008/3/1

N2 - DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

AB - DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

U2 - 10.1038/nrc2342

DO - 10.1038/nrc2342

M3 - Review article

C2 - 18256616

SN - 1474-1768

VL - 8

SP - 193

EP - 204

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 3

ER -

DNA repair pathways as targets for cancer therapy

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this