DNA repair pathways as targets for cancer therapy

T Helleday; Eva Petermann; C Lundin; B Hodgson; RA Sharma

doi:10.1038/nrc2342

DNA repair pathways as targets for cancer therapy

T Helleday, Eva Petermann, C Lundin, B Hodgson, RA Sharma

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

Original language	English
Pages (from-to)	193-204
Number of pages	12
Journal	Nature Reviews Cancer
Volume	8
Issue number	3
DOIs	https://doi.org/10.1038/nrc2342
Publication status	Published - 1 Mar 2008

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10.1038/nrc2342

Helleday_2008_NatureReviewsCancer
The definitive, peer-reviewed and edited version of this article is published in Nature Reviews Science, volume 8, issue 3, 2008 [http://dx.doi.org/10.1038/nrc2342]"
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AB - DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.

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DNA repair pathways as targets for cancer therapy

Abstract

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