When ceramides meet immune senescence, a GIMAP5 connection

Atrayee Gope; Claudio Mauro

doi:10.1038/s41590-023-01736-2

When ceramides meet immune senescence, a GIMAP5 connection

Atrayee Gope, Claudio Mauro^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

Original language	English
Number of pages	2
Journal	Nature Immunology
DOIs	https://doi.org/10.1038/s41590-023-01736-2
Publication status	E-pub ahead of print - 23 Jan 2024

Bibliographical note

Acknowledgements
C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).

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title = "When ceramides meet immune senescence, a GIMAP5 connection",

abstract = "Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.",

author = "Atrayee Gope and Claudio Mauro",

note = "Acknowledgements C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).",

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AU - Mauro, Claudio

N1 - Acknowledgements C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/ SBSRF/22/31031[CM1]).

PY - 2024/1/23

Y1 - 2024/1/23

N2 - Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

AB - Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

U2 - 10.1038/s41590-023-01736-2

DO - 10.1038/s41590-023-01736-2

M3 - Comment/debate

C2 - 38263464

SN - 1529-2908

JO - Nature Immunology

JF - Nature Immunology

ER -

When ceramides meet immune senescence, a GIMAP5 connection

Abstract

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