20022024

Research activity per year

Personal profile

Biography

Professor Mauro graduated from the University of Naples “Federico II” in Italy with a combined 5-year BSc and MSc degree in Medical Biotechnology in 2002 followed by a PhD in Molecular Oncology and Endocrinology in 2007.

Research interests

The research in the Mauro’s group focuses on the interconnections between metabolic and inflammatory pathways and how systemic and cellular metabolic alterations in diseases with an inflammatory component lead to aberrant immune cell responses, which favour both the establishment and the propagation of inflammation. In particular, they investigate the mechanisms of metabolic control of T cell-mediated immune responses, including migration, differentiation and cytokine production in physiology and under metabolic stress.

  • One key area of their research is how small metabolites, like lactate, which accumulates locally in the inflamed tissue or systemically during acute and chronic inflammation, can impact the fate of the immune-inflammatory response via induction of  intracellular metabolic rewiring with immediate effect on broad range human diseases.
  • Another important aspect of their research is how fatty acids can impact the outcomes of an immune response, with repercussions on obesity-related diseases.

Overall, their studies indicate that interfering with metabolic pathways (i.e., lipid, glucose and oxidative metabolism) alters immune cell effector functions and can be exploited for therapy.

Their main research outputs are:

Professor Mauro research is embedded in the Institute of Inflammation and Ageing (IIA), Institute of Cardiovascular Sciences (ICVS), Institute of Metabolism and Systems Research (IMSR), Centre for Musculoskeletal Ageing (CMAR), Centre of Membrane Proteins and Receptors (COMPARE), Centre for Neurogenetics Research, and Biomedical Research Centre (BRC) Sarcopenia and Multi-morbidity, Thrombo-Inflammation and Women's Metabolic Health Units.

Professor Mauro is also active on engaging the public and the students communities:

 

Qualifications

  • Abilitazione Scientifica Nazionale (ASN) a Professore di I Fascia (Italy), 2023
  • Fellow of the Higher Education Academy (UK), 2016
  • PhD in Molecular Oncology and Endocrinology, University of Naples Federico II (Italy), 2007
  • Medical Biotechnology Degree (combined 5 year BSc and MSc programme, 1st class Honours), University of Naples Federico II (Italy), 2002
  • Classical Humanities High School Diploma, Virgilio Institute, Lecce (Italy), 1997

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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