The acute stress-induced immunoenhancement hypothesis

Kathryn Edwards, Victoria Burns, Christopher Ring, Douglas Carroll, Mark Drayson

Research output: Contribution to journalArticle

40 Citations (Scopus)


Acute stress, such as a bout of exercise, is accepted to cause an array of immunologic changes. Recently, it has been proposed that acute stress activation of the innate immune system might be harnessed as an adjuvant to enhance immune responses to antigen challenge. This review develops the acute stress-induced immunoenhancement hypothesis and its possible role as a vaccine adjuvant.
Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalExercise and Sport Sciences Reviews
Publication statusPublished - 1 Jul 2007


  • adjuvant
  • antibody response
  • vaccination
  • cell-mediated response
  • acute stress


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