Tetraspanin CD9 in cell migration.

D Powner, PM Kopp, SJ Monkley, DR Critchley, Fedor Berditchevski

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin1, one of the critical regulators of integrin activation, to focal adhesions: CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells.
Original languageEnglish
Pages (from-to)563-7
Number of pages5
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished - 1 Apr 2011

Fingerprint

Dive into the research topics of 'Tetraspanin CD9 in cell migration.'. Together they form a unique fingerprint.

Cite this