Tertiary Lymphoid Structures: Autoimmunity Goes Local

Elena Pipi, Saba Nayar, David H Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)
197 Downloads (Pure)


Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.

Original languageEnglish
Article number1952
JournalFrontiers in immunology
Publication statusPublished - 12 Sept 2018


  • B-cells
  • autoantibodies
  • germinal center response
  • glycosylation
  • tertiary lymphoid structures (TLS)


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