Tertiary Lymphoid Structures: Autoimmunity Goes Local

Elena Pipi; Saba Nayar; David H Gardner; Serena Colafrancesco; Charlotte Smith; Francesca Barone

doi:10.3389/fimmu.2018.01952

Tertiary Lymphoid Structures: Autoimmunity Goes Local

Elena Pipi, Saba Nayar, David H Gardner, Serena Colafrancesco, Charlotte Smith, Francesca Barone

Research output: Contribution to journal › Review article › peer-review

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Abstract

Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.

Original language	English
Article number	1952
Journal	Frontiers in immunology
Volume	9
DOIs	https://doi.org/10.3389/fimmu.2018.01952
Publication status	Published - 12 Sept 2018

Keywords

B-cells
autoantibodies
germinal center response
glycosylation
tertiary lymphoid structures (TLS)

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Pipi_et_al_2018_Tertiary_lymphoid_structures_Frontiers_ImmunologyFinal published version, 1.57 MBLicence: Creative Commons: Attribution (CC BY)

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title = "Tertiary Lymphoid Structures: Autoimmunity Goes Local",

abstract = "Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.",

keywords = "B-cells, autoantibodies, germinal center response, glycosylation, tertiary lymphoid structures (TLS)",

author = "Elena Pipi and Saba Nayar and Gardner, {David H} and Serena Colafrancesco and Charlotte Smith and Francesca Barone",

year = "2018",

month = sep,

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doi = "10.3389/fimmu.2018.01952",

language = "English",

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journal = "Frontiers in immunology",

issn = "1664-3224",

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TY - JOUR

T1 - Tertiary Lymphoid Structures

T2 - Autoimmunity Goes Local

AU - Pipi, Elena

AU - Nayar, Saba

AU - Gardner, David H

AU - Colafrancesco, Serena

AU - Smith, Charlotte

AU - Barone, Francesca

PY - 2018/9/12

Y1 - 2018/9/12

N2 - Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.

AB - Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.

KW - B-cells

KW - autoantibodies

KW - germinal center response

KW - glycosylation

KW - tertiary lymphoid structures (TLS)

U2 - 10.3389/fimmu.2018.01952

DO - 10.3389/fimmu.2018.01952

M3 - Review article

C2 - 30258435

SN - 1664-3224

VL - 9

JO - Frontiers in immunology

JF - Frontiers in immunology

M1 - 1952

ER -

Tertiary Lymphoid Structures: Autoimmunity Goes Local

Abstract

Keywords

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