TY - JOUR
T1 - Tertiary Lymphoid Structures
T2 - Autoimmunity Goes Local
AU - Pipi, Elena
AU - Nayar, Saba
AU - Gardner, David H
AU - Colafrancesco, Serena
AU - Smith, Charlotte
AU - Barone, Francesca
PY - 2018/9/12
Y1 - 2018/9/12
N2 - Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.
AB - Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune diseases. TLS present features of secondary lymphoid organs such as segregated T and B cell zones, presence of follicular dendritic cell networks, high endothelial venules and specialized lymphoid fibroblasts and display the mechanisms to support local adaptive immune responses toward locally displayed antigens. TLS detection in the tissue is often associated with poor prognosis of disease, auto-antibody production and malignancy development. This review focuses on the contribution of TLS toward the persistence of the inflammatory drive, the survival of autoreactive lymphocyte clones and post-translational modifications, responsible for the pathogenicity of locally formed autoantibodies, during autoimmune disease development.
KW - B-cells
KW - autoantibodies
KW - germinal center response
KW - glycosylation
KW - tertiary lymphoid structures (TLS)
U2 - 10.3389/fimmu.2018.01952
DO - 10.3389/fimmu.2018.01952
M3 - Review article
C2 - 30258435
SN - 1664-3224
VL - 9
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 1952
ER -