Spectrally resolved bioluminescence optical tomography

Hamid Dehghani; Scott C. Davis; Shudong Jiang; Brian W. Pogue; Keith D. Paulsen; Michael S. Patterson

doi:10.1364/OL.31.000365

Spectrally resolved bioluminescence optical tomography

Hamid Dehghani^*, Scott C. Davis, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen, Michael S. Patterson

^*Corresponding author for this work

Computer Science

Research output: Contribution to journal › Article › peer-review

Abstract

Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.

Original language	English
Pages (from-to)	365-367
Number of pages	3
Journal	Optics Letters
Volume	31
Issue number	3
DOIs	https://doi.org/10.1364/OL.31.000365
Publication status	Published - 1 Feb 2006

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Spectrally resolved bioluminescence optical tomography",

abstract = "Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.",

author = "Hamid Dehghani and Davis, {Scott C.} and Shudong Jiang and Pogue, {Brian W.} and Paulsen, {Keith D.} and Patterson, {Michael S.}",

year = "2006",

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doi = "10.1364/OL.31.000365",

language = "English",

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AU - Dehghani, Hamid

AU - Davis, Scott C.

AU - Jiang, Shudong

AU - Pogue, Brian W.

AU - Paulsen, Keith D.

AU - Patterson, Michael S.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.

AB - Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.

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JO - Optics Letters

JF - Optics Letters

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Spectrally resolved bioluminescence optical tomography

Abstract

ASJC Scopus subject areas

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