Spectrally constrained NIR tomography for breast imaging: Simulations and clinical results

Subhadra Srinivasan; Brian W. Pogue; Shudong Jiang; Hamid Dehghani; Keith D. Paulsen

doi:10.1117/12.590576

Spectrally constrained NIR tomography for breast imaging: Simulations and clinical results

Subhadra Srinivasan^*, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Keith D. Paulsen

^*Corresponding author for this work

Computer Science

Research output: Contribution to journal › Conference article › peer-review

Abstract

A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.

Original language	English
Article number	59
Pages (from-to)	293-300
Number of pages	8
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5693
DOIs	https://doi.org/10.1117/12.590576
Publication status	Published - 2005
Event	Optical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States Duration: 23 Jan 2005 → 26 Jan 2005

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.590576

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title = "Spectrally constrained NIR tomography for breast imaging: Simulations and clinical results",

abstract = "A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.",

author = "Subhadra Srinivasan and Pogue, {Brian W.} and Shudong Jiang and Hamid Dehghani and Paulsen, {Keith D.}",

year = "2005",

doi = "10.1117/12.590576",

language = "English",

volume = "5693",

pages = "293--300",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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TY - JOUR

T1 - Spectrally constrained NIR tomography for breast imaging

T2 - Optical Tomography and Spectroscopy of Tissue VI

AU - Srinivasan, Subhadra

AU - Pogue, Brian W.

AU - Jiang, Shudong

AU - Dehghani, Hamid

AU - Paulsen, Keith D.

PY - 2005

Y1 - 2005

N2 - A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.

AB - A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.

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DO - 10.1117/12.590576

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VL - 5693

SP - 293

EP - 300

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 59

Y2 - 23 January 2005 through 26 January 2005

ER -

Spectrally constrained NIR tomography for breast imaging: Simulations and clinical results

Abstract

ASJC Scopus subject areas

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