Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

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Abstract

Human γδ T lymphocytes have innate-like and adaptive-like functions and can circulate in blood or reside in tissues. They are activated by specific antigens recognized by their T-cell receptor and recognize infected and transformed cells, suggesting that cellular stress is involved in specific antigen expression. However, molecular characterization of stress-induced antigens remains elusive, hampering our understanding of the role of γδ T cells in cancer and infections. In the present study we identify annexin A2 as such stress-induced antigen known as a phospholipid-binding protein involved in tumorigenesis, redox potential regulation, and wound healing. Stress-mediated membrane exposure of annexin A2 could thus constitute a danger signal for γδ T cells to recognize various cell dysregulations and protect the host against cancer and infections.

Original languageEnglish
Pages (from-to)3163–3168
JournalNational Academy of Sciences. Proceedings
Volume114
Issue number12
Early online date7 Mar 2017
DOIs
Publication statusE-pub ahead of print - 7 Mar 2017

Keywords

  • innate-like lymphocytes
  • tumor immunology
  • cell stress surveillance
  • cytomegalovirus
  • gamma-delta T cells

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