Privileged Structures and Motifs (Synthetic and Natural Scaffolds)

A. M. Jones

doi:10.1016/B978-0-12-409547-2.12316-9

Privileged Structures and Motifs (Synthetic and Natural Scaffolds)

A. M. Jones^*

^*Corresponding author for this work

Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

In the constantly evolving world of drug discovery, there remains a constant: the privileged structure. In this article, we define and review the concept of the privileged structure. We focus on its applications and limitations, reviewing the main classes and introducing an updated clustering system based on the most commonly encountered structural features. Sources of these privileged scaffolds both synthetic and natural are exemplified. Finally, we look at "lead-like" synthesis and its future in privileged drug discovery.

Original language	English
Title of host publication	Drug Discovery Technologies
Publisher	Elsevier
Pages	116-152
Number of pages	37
Volume	2-8
ISBN (Electronic)	9780128032008
ISBN (Print)	9780128032015
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.12316-9
Publication status	Published - 3 Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd. All rights reserved.

Keywords

Chemical probe
Diversity-oriented synthesis
Drug design
Drug discovery
Lead structures
Lead-like
Library design
Natural products
Privileged structures
Synthetic structures

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1016/B978-0-12-409547-2.12316-9

Cite this

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AB - In the constantly evolving world of drug discovery, there remains a constant: the privileged structure. In this article, we define and review the concept of the privileged structure. We focus on its applications and limitations, reviewing the main classes and introducing an updated clustering system based on the most commonly encountered structural features. Sources of these privileged scaffolds both synthetic and natural are exemplified. Finally, we look at "lead-like" synthesis and its future in privileged drug discovery.

KW - Chemical probe

KW - Diversity-oriented synthesis

KW - Drug design

KW - Drug discovery

KW - Lead structures

KW - Lead-like

KW - Library design

KW - Natural products

KW - Privileged structures

KW - Synthetic structures

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M3 - Chapter

AN - SCOPUS:85046115375

SN - 9780128032015

VL - 2-8

SP - 116

EP - 152

BT - Drug Discovery Technologies

PB - Elsevier

ER -

Privileged Structures and Motifs (Synthetic and Natural Scaffolds)

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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