Parameter estimation and simulations of a mathematical model of Corynebacterium pseudotuberculosis transmission in sheep

K. M. O'Reilly, L. E. Green, F. E. Malone, G. F. Medley

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Caseous lymphadenitis (CLA) is an infectious disease of sheep caused by Corynebacterium pseudotuberculosis. It is prevalent in most sheep producing countries and was introduced into the UK sheep population in 1991. The pathogen invades the host through epithelium and forms an abscess in the local draining lymph node. Typically, disease presents as clinical, with overt (externally visible) swollen lymph nodes (the parotid, submandibular, prefemoral, prescapular, popliteal or mammary) or sub-clinical, with abscesses in the lungs and associated thoracic (bronchial and mediastinal) lymph nodes. We present a mathematical model in which disease is categorised as overt and/or respiratory (sub-clinical), using the above groupings. In both situations sheep may be infected and may or may not be infectious. In the model, overt abscesses may resolve and respiratory abscesses are considered to be present for life. Using the location of the abscesses, three routes of transmission are postulated: overt to overt, respiratory to overt and respiratory to respiratory. Data from four naturally infected flocks were used to describe populations of sheep with epidemic CLA and to estimate transmission coefficients for each of the postulated transmission routes. The infection process parameters were derived from literature where possible. Parameters were estimated using maximum likelihood methods and compared to the data using a multinomial distribution. The distribution of abscesses in the flocks was similar to endemic data reported in other studies. In the model most infected sheep developed abscesses, and approximately 36% of sheep with overt abscesses recovered from infection. The average time for respiratory abscesses to become infectious was 41 days. In these data, overt to overt transmission was the most frequent route of transmission since it had the highest coefficient in the model compared with respiratory to overt and respiratory to respiratory transmission. Transmission coefficients specific for each flock significantly (P < 0.05) improved the model fit to the data. In simulations using values of best-fitting parameter combinations, the proportion of sheep infected was between 0.39 and 0.60 at equilibrium. This is the first mathematical model of C. pseudotuberculosis infection, the parameter estimates indicate that aspects of the infection process could be utilised to design control strategies. Crown

Original languageEnglish
Pages (from-to)242-259
Number of pages18
JournalPreventive Veterinary Medicine
Volume83
Issue number3-4
DOIs
Publication statusPublished - 17 Mar 2008

Bibliographical note

Funding Information:
Kath O’ Reilly was supported by a BBSRC studentship. We thank Michael Paton for helpful discussions and Fiona Murdock for case reports of the flocks in the study.

Keywords

  • Caseous lymphadenitis
  • Corynebacterium pseudotuberculosis
  • Mathematical model
  • Maximum likelihood

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

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