Projects per year
Abstract
Introduction: Community-acquired pneumonia has high mortality and is associated with significant healthcare costs. In older adults with community-acquired pneumonia neutrophil dysfunction has been identified and is associated with poor outcomes for patients. Immunometabolism is a rapidly developing field which links immune cell function to metabolism. This study aims to explore neutrophil metabolism in community-acquired pneumonia. Methods and analysis: Pneumonia Metabolism in Ageing study is a prospective observational study recruiting older adults hospitalised with community-acquired pneumonia to examine neutrophil function and metabolic status. Controls will be older adults with no acute illness. The primary endpoint is neutrophil chemotaxis. Ethics and dissemination: The study has ethical approval from the Research Ethics Committee Wales, reference 19/WA/0299. This study involves participants who may lack the capacity to consent to research involvement, in this situation, personal or professional assent will be sought. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at local and international conferences.
Original language | English |
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Article number | e001806 |
Number of pages | 7 |
Journal | BMJ Open Respiratory Research |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 12 Oct 2023 |
Keywords
- Innate Immunity
- Bacterial Infection
- Respiratory Infection
- Pneumonia
- Neutrophil Biology
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Efficacy and Mechanism Evaluation -Effectiveness of Electronic Cigarettes compared with varenicline for smoking cessation in patients with COPD and effect on the Lungs (EME-ECAL study)
Scott, A., Sapey, E., Handley, K., Thickett, D., Parekh, D. & Farley, A.
1/03/23 → 28/02/26
Project: Other Government Departments
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Effectiveness of Electronic Cigarettes compared with varenicline for smoking cessation in patients with chronic obstructive pulmonary disease and effect on Lung health (ECAL study)
Scott, A., Handley, K., Sapey, E., Adab, P., Jowett, S., Farley, A., Jordan, R., Parekh, D. & Thickett, D.
1/09/22 → 30/09/25
Project: Other Government Departments
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Does hospitalisation of older patients with severe community acquired pneumonia and sepsis lead to long term
Sapey, E., Thickett, D., Richter, A., Patel, J., Mitchell, T. & Scott, A.
1/07/19 → 30/06/23
Project: Research Councils