Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Weihao Fan; Hamid Dehghani; Adam T. Eggebrecht

doi:10.1117/12.2610185

Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Weihao Fan, Hamid Dehghani, Adam T. Eggebrecht

Computer Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.

Original language	English
Title of host publication	Clinical and Translational Neurophotonics 2022
Editors	Victor X. D. Yang, Jana M. Kainerstorfer
Publisher	SPIE
ISBN (Electronic)	9781510647619
DOIs	https://doi.org/10.1117/12.2610185
Publication status	Published - 4 Mar 2022
Event	Clinical and Translational Neurophotonics 2022 - Virtual, Online Duration: 20 Feb 2022 → 24 Feb 2022

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11945
ISSN (Print)	1605-7422

Conference

Conference	Clinical and Translational Neurophotonics 2022
City	Virtual, Online
Period	20/02/22 → 24/02/22

Bibliographical note

Publisher Copyright:
© 2022 SPIE.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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Cite this

Fan, W., Dehghani, H., & Eggebrecht, A. T. (2022). Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography. In V. X. D. Yang, & J. M. Kainerstorfer (Eds.), Clinical and Translational Neurophotonics 2022 Article 1194506 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11945). SPIE. https://doi.org/10.1117/12.2610185

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title = "Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography",

abstract = "We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.",

author = "Weihao Fan and Hamid Dehghani and Eggebrecht, {Adam T.}",

note = "Publisher Copyright: {\textcopyright} 2022 SPIE.; Clinical and Translational Neurophotonics 2022 ; Conference date: 20-02-2022 Through 24-02-2022",

year = "2022",

month = mar,

day = "4",

doi = "10.1117/12.2610185",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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Fan, W, Dehghani, H & Eggebrecht, AT 2022, Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography. in VXD Yang & JM Kainerstorfer (eds), Clinical and Translational Neurophotonics 2022., 1194506, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11945, SPIE, Clinical and Translational Neurophotonics 2022, Virtual, Online, 20/02/22. https://doi.org/10.1117/12.2610185

Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography. / Fan, Weihao; Dehghani, Hamid; Eggebrecht, Adam T.
Clinical and Translational Neurophotonics 2022. ed. / Victor X. D. Yang; Jana M. Kainerstorfer. SPIE, 2022. 1194506 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11945).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

AU - Fan, Weihao

AU - Dehghani, Hamid

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N2 - We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.

AB - We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.

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Y2 - 20 February 2022 through 24 February 2022

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Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Abstract

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ASJC Scopus subject areas

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