Abstract
Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P
Original language | English |
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Pages (from-to) | 3807-3817 |
Number of pages | 11 |
Journal | Blood |
Volume | 112 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Nov 2008 |