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PhD projects

Tatjana Stankovic’s research is focused on an elucidation of the role of ataxia telangiectasia mutated (ATM) and other DNA damage response genes in the multistep process of leukaemia/ lymphomagenesis. Particular emphasis is given to DNA damage response defects that can be targeted for tumour-specific treatment. Therefore, a long-term goal is to translate the understanding of DNA damage response pathways in haematopoietic malignancies into novel therapeutic strategies. Current and future studies focus on:

Identification of a network of ATM-dependent cellular responses and DNA repair defects that can be targeted for treatment in chronic leukaemia
Addressing different mechanisms of tumorigenesis and novel therapeutic approaches in mouse models of ATM-deficient haematopoietic malignancies
Studying the effect of histone deacetylase (HDAC) inhibitors and demethylating agents on immune responses in acute myeloid leukaemia (AML)
Identifying activated kinases and DNA repair proteins that cause chemoresistance in paediatric acute lymphoblastic leukaemia (ALL)


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Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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