IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14)

S Feyler; SJ O'Connor; AC Rawstron; C Subash; FM Ross; Guy Pratt; Mark Drayson; J Ashcroft; G Cook; RG Owen

doi:10.1111/j.1365-2141.2007.06969.x

IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14)

S Feyler, SJ O'Connor, AC Rawstron, C Subash, FM Ross, Guy Pratt, Mark Drayson, J Ashcroft, G Cook, RG Owen

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Abstract

IgM myeloma is a very rare and poorly defined entity. In a detailed assessment of 10 cases, it was demonstrated that 70% had an aberrant phenotype based on the expression of CD19, CD45, CD27 and Cyclin D1 but all cases lacked CD56 and CD117. Interphase fluorescence in situ hybridization demonstrated deletion 13 in 50% while 5/8 cases assessed had a t(11;14). Despite the high incidence of the t(11;14), CD20 was only expressed in one of nine cases. We conclude that IgM myeloma is a distinctive subset characterized by a CD20-CD56-CD117- phenotype and the t(11;14).

Original language	English
Pages (from-to)	547-51
Number of pages	5
Journal	British Journal of Haematology
Volume	140
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06969.x
Publication status	Published - 1 Mar 2008

Keywords

myeloma
t(11;14)
immunophenotype
genotype
IgM

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10.1111/j.1365-2141.2007.06969.x

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abstract = "IgM myeloma is a very rare and poorly defined entity. In a detailed assessment of 10 cases, it was demonstrated that 70% had an aberrant phenotype based on the expression of CD19, CD45, CD27 and Cyclin D1 but all cases lacked CD56 and CD117. Interphase fluorescence in situ hybridization demonstrated deletion 13 in 50% while 5/8 cases assessed had a t(11;14). Despite the high incidence of the t(11;14), CD20 was only expressed in one of nine cases. We conclude that IgM myeloma is a distinctive subset characterized by a CD20-CD56-CD117- phenotype and the t(11;14).",

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T1 - IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14)

AU - Feyler, S

AU - O'Connor, SJ

AU - Rawstron, AC

AU - Subash, C

AU - Ross, FM

AU - Pratt, Guy

AU - Drayson, Mark

AU - Ashcroft, J

AU - Cook, G

AU - Owen, RG

PY - 2008/3/1

Y1 - 2008/3/1

N2 - IgM myeloma is a very rare and poorly defined entity. In a detailed assessment of 10 cases, it was demonstrated that 70% had an aberrant phenotype based on the expression of CD19, CD45, CD27 and Cyclin D1 but all cases lacked CD56 and CD117. Interphase fluorescence in situ hybridization demonstrated deletion 13 in 50% while 5/8 cases assessed had a t(11;14). Despite the high incidence of the t(11;14), CD20 was only expressed in one of nine cases. We conclude that IgM myeloma is a distinctive subset characterized by a CD20-CD56-CD117- phenotype and the t(11;14).

AB - IgM myeloma is a very rare and poorly defined entity. In a detailed assessment of 10 cases, it was demonstrated that 70% had an aberrant phenotype based on the expression of CD19, CD45, CD27 and Cyclin D1 but all cases lacked CD56 and CD117. Interphase fluorescence in situ hybridization demonstrated deletion 13 in 50% while 5/8 cases assessed had a t(11;14). Despite the high incidence of the t(11;14), CD20 was only expressed in one of nine cases. We conclude that IgM myeloma is a distinctive subset characterized by a CD20-CD56-CD117- phenotype and the t(11;14).

KW - myeloma

KW - t(11;14)

KW - immunophenotype

KW - genotype

KW - IgM

U2 - 10.1111/j.1365-2141.2007.06969.x

DO - 10.1111/j.1365-2141.2007.06969.x

M3 - Article

C2 - 18275432

SN - 1365-2141

VL - 140

SP - 547

EP - 551

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

IgM myeloma: a rare entity characterized by a CD20-CD56-CD117- immunophenotype and the t(11;14)

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Keywords

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