Health-related quality of life around the time of diagnosis in patients with bladder cancer

Evan Yu, Duncan Nekeman, Neil Aaronson, Lucinda Billingham, Nicholas James, K. K. Cheng, Rik Bryan, Anke Wesselius, Maurice Zeegers

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3 Citations (Scopus)
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Objectives: To quantify the health-related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two-factor model for the HRQoL questionnaire QLQ-C30. Methods: From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi-structured face-to-face interviews. Answers to the QLQ-C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two-factor (Physical and Mental Health) domain structure of the QLQ-C30 was also tested with confirmatory factor analyses (CFA). Results: A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non-muscle-invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ-C30 scores. The CFA showed an overall good fit of the hypothesized two-factor model. Conclusion: This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two-factor (Physical and Mental Health) model was developed for the QLQ-C30.

Original languageEnglish
Pages (from-to)984-991
Number of pages8
JournalBJU International
Issue number6
Early online date11 May 2019
Publication statusPublished - 1 Dec 2019


  • bladder cancer
  • quality of life
  • cohort study
  • QLQ-C30 questionnaire


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