Green electrosynthesis of drug metabolites

Ridho Asra, Alan M Jones*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

In this concise review, the field of electrosynthesis (ES) as a green methodology for understanding drug metabolites linked to toxicology is exemplified. ES describes the synthesis of chemical compounds in an electrochemical cell. Compared to a conventional chemical reaction, ES operates under green conditions (the electron is the reagent) and has several industrial applications, including the synthesis of drug metabolites for toxicology testing. Understanding which circulating drug metabolites are formed in the body is a crucial stage in the development of new medicines and gives insight into any potential toxic pathologies resulting from the metabolites formed. Current methods to prepare drug metabolites directly from the drug molecule often involve time-consuming multistep syntheses. Throughout this review, the application of green ES to (i) identify drug metabolites, (ii) enable their efficient synthesis, and (iii) investigate the toxicity of the metabolites generated are highlighted.
Original languageEnglish
Article numbertfad009
Pages (from-to)1-28
Number of pages28
JournalToxicology Research
Early online date7 Mar 2023
DOIs
Publication statusE-pub ahead of print - 7 Mar 2023

Keywords

  • metabolite
  • electrosynthesis
  • drug

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