Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh; Maliheh Entezari; Sepideh Mirzaei; Amirhossein Zabolian; Hossein Saleki; Mohamad Javad Naghdi; Sina Sabet; Mohammad Amin Khoshbakht; Mehrdad Hashemi; Kiavash Hushmandi; Gautam Sethi; Ali Zarrabi; Alan Prem Kumar; Shing Cheng Tan; Marios Papadakis; Athanasios Alexiou; Md Asiful Islam; Ebrahim Mostafavi; Milad Ashrafizadeh

doi:10.1186/s13045-022-01305-4

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Mahshid Deldar Abad Paskeh, Maliheh Entezari, Sepideh Mirzaei, Amirhossein Zabolian, Hossein Saleki, Mohamad Javad Naghdi, Sina Sabet, Mohammad Amin Khoshbakht, Mehrdad Hashemi, Kiavash Hushmandi, Gautam Sethi, Ali Zarrabi, Alan Prem Kumar, Shing Cheng Tan^*, Marios Papadakis^*, Athanasios Alexiou, Md Asiful Islam, Ebrahim Mostafavi, Milad Ashrafizadeh^*

^*Corresponding author for this work

Metabolism and Systems Research

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

2 Downloads (Pure)

Abstract

Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.].

Original language	English
Article number	83
Number of pages	39
Journal	Journal of Hematology and Oncology
Volume	15
Issue number	1
Early online date	28 Jun 2022
DOIs	https://doi.org/10.1186/s13045-022-01305-4
Publication status	Published - Dec 2022

Bibliographical note

Funding Information:
Open Access funding enabled and organized by Projekt DEAL. The work was supported by a grant from the Singapore Ministry of Education Tier 2 (MOE-T2EP30120-0016) to A.P.K. A.P.K. is also supported by the National Medical Research Council of Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore. S.C.T. is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076) and the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9).

Publisher Copyright:
© 2022, The Author(s).

Keywords

Biomarker
Cancer
Exosome
Immunotherapy
Non-coding RNA
Prognosis

ASJC Scopus subject areas

Molecular Biology
Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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PaskehM2022EmergingFinal published version, 4.52 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

Paskeh, M. D. A., Entezari, M., Mirzaei, S., Zabolian, A., Saleki, H., Naghdi, M. J., Sabet, S., Khoshbakht, M. A., Hashemi, M., Hushmandi, K., Sethi, G., Zarrabi, A., Kumar, A. P., Tan, S. C., Papadakis, M., Alexiou, A., Islam, M. A., Mostafavi, E., & Ashrafizadeh, M. (2022). Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. Journal of Hematology and Oncology, 15(1), Article 83. https://doi.org/10.1186/s13045-022-01305-4

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abstract = "Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.].",

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author = "Paskeh, {Mahshid Deldar Abad} and Maliheh Entezari and Sepideh Mirzaei and Amirhossein Zabolian and Hossein Saleki and Naghdi, {Mohamad Javad} and Sina Sabet and Khoshbakht, {Mohammad Amin} and Mehrdad Hashemi and Kiavash Hushmandi and Gautam Sethi and Ali Zarrabi and Kumar, {Alan Prem} and Tan, {Shing Cheng} and Marios Papadakis and Athanasios Alexiou and Islam, {Md Asiful} and Ebrahim Mostafavi and Milad Ashrafizadeh",

note = "Funding Information: Open Access funding enabled and organized by Projekt DEAL. The work was supported by a grant from the Singapore Ministry of Education Tier 2 (MOE-T2EP30120-0016) to A.P.K. A.P.K. is also supported by the National Medical Research Council of Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore. S.C.T. is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076) and the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9). Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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Paskeh, MDA, Entezari, M, Mirzaei, S, Zabolian, A, Saleki, H, Naghdi, MJ, Sabet, S, Khoshbakht, MA, Hashemi, M, Hushmandi, K, Sethi, G, Zarrabi, A, Kumar, AP, Tan, SC, Papadakis, M, Alexiou, A, Islam, MA, Mostafavi, E & Ashrafizadeh, M 2022, 'Emerging role of exosomes in cancer progression and tumor microenvironment remodeling', Journal of Hematology and Oncology, vol. 15, no. 1, 83. https://doi.org/10.1186/s13045-022-01305-4

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AU - Paskeh, Mahshid Deldar Abad

AU - Entezari, Maliheh

AU - Mirzaei, Sepideh

AU - Zabolian, Amirhossein

AU - Saleki, Hossein

AU - Naghdi, Mohamad Javad

AU - Sabet, Sina

AU - Khoshbakht, Mohammad Amin

AU - Hashemi, Mehrdad

AU - Hushmandi, Kiavash

AU - Sethi, Gautam

AU - Zarrabi, Ali

AU - Kumar, Alan Prem

AU - Tan, Shing Cheng

AU - Papadakis, Marios

AU - Alexiou, Athanasios

AU - Islam, Md Asiful

AU - Mostafavi, Ebrahim

AU - Ashrafizadeh, Milad

N1 - Funding Information: Open Access funding enabled and organized by Projekt DEAL. The work was supported by a grant from the Singapore Ministry of Education Tier 2 (MOE-T2EP30120-0016) to A.P.K. A.P.K. is also supported by the National Medical Research Council of Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore. S.C.T. is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076) and the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9). Publisher Copyright: © 2022, The Author(s).

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N2 - Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.].

AB - Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.].

KW - Biomarker

KW - Cancer

KW - Exosome

KW - Immunotherapy

KW - Non-coding RNA

KW - Prognosis

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M3 - Review article

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ER -

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this