Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

Sian Faustini; Adrian Shields; Gemma Banham; Nadezhda Wall; Saly Al-Taei; Chloe Tanner; Zahra Ahmed; Elena Efstathiou; Neal Townsend; Margaret Goodall; Tim Plant; Marisol Perez-Toledo; Aleksandra Jasiulewicz; Ruth Price; James Mclaughlin; John Farnan; Julie Moore; Louise Robertson; Andrew Nesbit; Grace Curry; Amy Black; Adam Cunningham; Lorraine Harper; Tara Moore; Mark Drayson; Alex Richter

doi:10.1016/j.jinf.2022.01.002

Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

Sian Faustini, Adrian Shields, Gemma Banham, Nadezhda Wall, Saly Al-Taei, Chloe Tanner, Zahra Ahmed, Elena Efstathiou, Neal Townsend, Margaret Goodall, Tim Plant, Marisol Perez-Toledo, Aleksandra Jasiulewicz, Ruth Price, James Mclaughlin, John Farnan, Julie Moore, Louise Robertson, Andrew Nesbit, Grace CurryAmy Black, Adam Cunningham, Lorraine Harper, Tara Moore, Mark Drayson, Alex Richter^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	579-613
Number of pages	35
Journal	Journal of Infection
Volume	84
Issue number	4
Early online date	10 Jan 2022
DOIs	https://doi.org/10.1016/j.jinf.2022.01.002
Publication status	Published - Apr 2022

Bibliographical note

Acknowledgments:
We thank the staff and patients that have kindly volunteered for this study. Thanks also to Abingdon Health for the Wuhan and Delta antigens. The authors would like to acknowledge the COVID-HD Birmingham Study Group and PITCH consortium that have enabled this work, the staff of the Clinical Immunology Service, managed by Tim Plant, who helped process the healthcare worker and haemodialysis samples and Dr. Margaret Goodall for her expertise in antibody production and assay development. The authors would also like to acknowledge the National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility and University Hospitals Birmingham Research and Development team, in particular the research nurses that enabled the sample consent and sample collection including Mary Dutton, Lesley Fifer, Sinead White, Natalie Walmsley-Allen, Lucy Atchinson-Jones, Kulli Kuningas, Margaret Carmody, Rani Maria Joseph, Christopher McGhee, Shannon Page and Michelle Bates. Also, The Ulster Pandemic Study team. The COCO/PITCH healthcare worker cohort was funded by the United Kingdom Department of Health and Social Care and United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call as part of the PITCH Consortium. The HD cohort was funded by the United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call. The COVID-HD Birmingham Study Group include Claire Backhouse, Anna Casey, Lynsey Dunbar, Beena Emmanuel, Megan Fahy, Alexandra Godlee, Paul Moss, Peter Nightingale, Liz Ratcliffe, Stephanie Stringer, Matthew Tabinor, Sian Faustini, Adam Cunningham, Alex Richter, Lorraine Harper. The PITCH study Group include Susanna Dunachie, Paul Klenerman, Lance Turtle, Thushan de Silva, Christopher Duncan, Rebecca Payne, Alex Richter, Ellie Barnes, Miles Carroll, Alexandra Deeks, Christina Dold.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Faustini, S., Shields, A., Banham, G., Wall, N., Al-Taei, S., Tanner, C., Ahmed, Z., Efstathiou, E., Townsend, N., Goodall, M., Plant, T., Perez-Toledo, M., Jasiulewicz, A., Price, R., Mclaughlin, J., Farnan, J., Moore, J., Robertson, L., Nesbit, A., ... Richter, A. (2022). Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals. Journal of Infection, 84(4), 579-613. https://doi.org/10.1016/j.jinf.2022.01.002

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title = "Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals",

author = "Sian Faustini and Adrian Shields and Gemma Banham and Nadezhda Wall and Saly Al-Taei and Chloe Tanner and Zahra Ahmed and Elena Efstathiou and Neal Townsend and Margaret Goodall and Tim Plant and Marisol Perez-Toledo and Aleksandra Jasiulewicz and Ruth Price and James Mclaughlin and John Farnan and Julie Moore and Louise Robertson and Andrew Nesbit and Grace Curry and Amy Black and Adam Cunningham and Lorraine Harper and Tara Moore and Mark Drayson and Alex Richter",

note = "Acknowledgments: We thank the staff and patients that have kindly volunteered for this study. Thanks also to Abingdon Health for the Wuhan and Delta antigens. The authors would like to acknowledge the COVID-HD Birmingham Study Group and PITCH consortium that have enabled this work, the staff of the Clinical Immunology Service, managed by Tim Plant, who helped process the healthcare worker and haemodialysis samples and Dr. Margaret Goodall for her expertise in antibody production and assay development. The authors would also like to acknowledge the National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility and University Hospitals Birmingham Research and Development team, in particular the research nurses that enabled the sample consent and sample collection including Mary Dutton, Lesley Fifer, Sinead White, Natalie Walmsley-Allen, Lucy Atchinson-Jones, Kulli Kuningas, Margaret Carmody, Rani Maria Joseph, Christopher McGhee, Shannon Page and Michelle Bates. Also, The Ulster Pandemic Study team. The COCO/PITCH healthcare worker cohort was funded by the United Kingdom Department of Health and Social Care and United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call as part of the PITCH Consortium. The HD cohort was funded by the United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call. The COVID-HD Birmingham Study Group include Claire Backhouse, Anna Casey, Lynsey Dunbar, Beena Emmanuel, Megan Fahy, Alexandra Godlee, Paul Moss, Peter Nightingale, Liz Ratcliffe, Stephanie Stringer, Matthew Tabinor, Sian Faustini, Adam Cunningham, Alex Richter, Lorraine Harper. The PITCH study Group include Susanna Dunachie, Paul Klenerman, Lance Turtle, Thushan de Silva, Christopher Duncan, Rebecca Payne, Alex Richter, Ellie Barnes, Miles Carroll, Alexandra Deeks, Christina Dold.",

year = "2022",

month = apr,

doi = "10.1016/j.jinf.2022.01.002",

language = "English",

volume = "84",

pages = "579--613",

journal = "Journal of Infection",

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Faustini, S , Shields, A, Banham, G, Wall, N, Al-Taei, S, Tanner, C, Ahmed, Z, Efstathiou, E, Townsend, N, Goodall, M, Plant, T, Perez-Toledo, M, Jasiulewicz, A, Price, R, Mclaughlin, J, Farnan, J, Moore, J, Robertson, L, Nesbit, A, Curry, G, Black, A, Cunningham, A, Harper, L, Moore, T, Drayson, M & Richter, A 2022, 'Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals', Journal of Infection, vol. 84, no. 4, pp. 579-613. https://doi.org/10.1016/j.jinf.2022.01.002

TY - JOUR

T1 - Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

AU - Faustini, Sian

AU - Shields, Adrian

AU - Banham, Gemma

AU - Wall, Nadezhda

AU - Al-Taei, Saly

AU - Tanner, Chloe

AU - Ahmed, Zahra

AU - Efstathiou, Elena

AU - Townsend, Neal

AU - Goodall, Margaret

AU - Plant, Tim

AU - Perez-Toledo, Marisol

AU - Jasiulewicz, Aleksandra

AU - Price, Ruth

AU - Mclaughlin, James

AU - Farnan, John

AU - Moore, Julie

AU - Robertson, Louise

AU - Nesbit, Andrew

AU - Curry, Grace

AU - Black, Amy

AU - Cunningham, Adam

AU - Harper, Lorraine

AU - Moore, Tara

AU - Drayson, Mark

AU - Richter, Alex

N1 - Acknowledgments: We thank the staff and patients that have kindly volunteered for this study. Thanks also to Abingdon Health for the Wuhan and Delta antigens. The authors would like to acknowledge the COVID-HD Birmingham Study Group and PITCH consortium that have enabled this work, the staff of the Clinical Immunology Service, managed by Tim Plant, who helped process the healthcare worker and haemodialysis samples and Dr. Margaret Goodall for her expertise in antibody production and assay development. The authors would also like to acknowledge the National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility and University Hospitals Birmingham Research and Development team, in particular the research nurses that enabled the sample consent and sample collection including Mary Dutton, Lesley Fifer, Sinead White, Natalie Walmsley-Allen, Lucy Atchinson-Jones, Kulli Kuningas, Margaret Carmody, Rani Maria Joseph, Christopher McGhee, Shannon Page and Michelle Bates. Also, The Ulster Pandemic Study team. The COCO/PITCH healthcare worker cohort was funded by the United Kingdom Department of Health and Social Care and United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call as part of the PITCH Consortium. The HD cohort was funded by the United Kingdom Research and Innovation COVID-19 Rapid Response Rolling Call. The COVID-HD Birmingham Study Group include Claire Backhouse, Anna Casey, Lynsey Dunbar, Beena Emmanuel, Megan Fahy, Alexandra Godlee, Paul Moss, Peter Nightingale, Liz Ratcliffe, Stephanie Stringer, Matthew Tabinor, Sian Faustini, Adam Cunningham, Alex Richter, Lorraine Harper. The PITCH study Group include Susanna Dunachie, Paul Klenerman, Lance Turtle, Thushan de Silva, Christopher Duncan, Rebecca Payne, Alex Richter, Ellie Barnes, Miles Carroll, Alexandra Deeks, Christina Dold.

PY - 2022/4

Y1 - 2022/4

U2 - 10.1016/j.jinf.2022.01.002

DO - 10.1016/j.jinf.2022.01.002

M3 - Letter

SN - 0163-4453

VL - 84

SP - 579

EP - 613

JO - Journal of Infection

JF - Journal of Infection

IS - 4

ER -