TY - JOUR
T1 - Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: A preliminary study
AU - Burns, Victoria
AU - Ring, Christopher
AU - Drayson, Mark
AU - Carroll, Douglas
PY - 2002/5/1
Y1 - 2002/5/1
N2 - This study examined possible neuroendocrine mechanisms underlying the association between stress and antibody response to vaccination. Hepatitis B antibody titers were obtained, and salivary cortisol and cardiovascular activity measured during baseline, mental arithmetic, and recovery in 30 undergraduates. It was hypothesised that higher reactivity would be associated with poorer antibody status. Compared to individuals with high antibody titers, those with low titers had significantly lower cortisol levels throughout, exhibited a significantly attenuated end-of-task reduction in cortisol relative to resting baseline, and had larger cardiac output and inotropic reactions, but smaller increases in total peripheral resistance, to mental arithmetic. In sum, variations in indices of both hypothalamic pituitary adrenocortical axis and sympathetic nervous system activity were associated with individual differences in immune response to vaccination.
AB - This study examined possible neuroendocrine mechanisms underlying the association between stress and antibody response to vaccination. Hepatitis B antibody titers were obtained, and salivary cortisol and cardiovascular activity measured during baseline, mental arithmetic, and recovery in 30 undergraduates. It was hypothesised that higher reactivity would be associated with poorer antibody status. Compared to individuals with high antibody titers, those with low titers had significantly lower cortisol levels throughout, exhibited a significantly attenuated end-of-task reduction in cortisol relative to resting baseline, and had larger cardiac output and inotropic reactions, but smaller increases in total peripheral resistance, to mental arithmetic. In sum, variations in indices of both hypothalamic pituitary adrenocortical axis and sympathetic nervous system activity were associated with individual differences in immune response to vaccination.
KW - sympathetic nervous system
KW - mental stress
KW - hepatitis B vaccination
KW - cortisol
KW - cardiovascular activity
KW - hypothalamic pituitary adrenocortical axis
UR - http://www.scopus.com/inward/record.url?scp=0036245502&partnerID=8YFLogxK
U2 - 10.1017/S0048577201393022
DO - 10.1017/S0048577201393022
M3 - Article
C2 - 12212655
VL - 39
SP - 361
EP - 368
JO - Psychophysiology
JF - Psychophysiology
IS - 3
ER -