Copper(II)‐induced fluorescence quenching of a BODIPY fluorophore

Dirk-Peter Herten, Andreas Haderspeck, Felix Braun, Hubert Wadepohl

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The ongoing developments in fluorescence microscopy have pushed the interest in new fluorescent probes with specific properties. Aside of controlling emissive states by light irradiation, defined control by changing the chemical environment has come into focus. In this context, we designed a fluorescent probe by conjugation of bipyridine, acting as sensor for CuII, to a BODIPY derivative at the shortest possible distance between sensor and chromophore. Herein, we present the synthesis of the BODIPY probe along with its crystal structure. We found a strong dependence of absorption and emission upon CuII complex formation decreasing the fluorescence quantum yield to ca. 1 % in respect to the pure probe. We hypothesize that further functionalization with a linker could make this compound and interesting probe for fluorescence microscopy.
Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalZeitschrift fur Anorganische und Allgemeine Chemie
Issue number14
Publication statusPublished - 2 Aug 2018

Bibliographical note

Dedicated to Professor Peter Comba on the Occasion of his 65th Birthday


  • fluorescent switches
  • metal ion sensing
  • copper
  • boron-dippyrromethene (BODIPY)
  • fluorescence spectroscopy


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