Research output per year
Research output per year
Personal profile
Biography
Dirk graduated from the Heidelberg Department of Physical Chemistry in 2000 after studying Chemistry at the Heidelberg University, Germany.
After collecting experiences in industry at ATTO-TEC GmbH, Germany he returned to academia in 2002 by specializing in single-molecule spectroscopy at Heidelberg University where he was awarded the venia legendi in Physical Chemistry in 2008. In 2015 he became University Professor in Single-Molecule Spectroscopy at Heidelberg University until accepting a Chair in Cell Biology of Membrane Proteins at the University of Birmingham in 2019.
Research interests
Dirk researches tools to enable quantitative studies of the composition and dynamics of cellular structures and enzymatic reactions in living cells. This highly interdisciplinary research will improve our general understanding of intracellular functions and cellular responses to external stimuli in the context of various diseases by bridging biochemistry and cell biology. The design of fluorescent probes for live-cell single-molecule studies has potential for biomedical research and diagnostic applications.
Dirk is currently active in three areas in single-molecule research: single photon based molecular counting, switchable fluorescent probes for advanced fluorescence microscopy, e.g. super-resolution in living cells, and single-molecule studies of chemical reaction pathways.
Qualifications
- Venia legendi in Physical Chemistry 2008
- PhD in Physical Chemistry 2000
- Diploma in Chemistry, Heidelberg University 1996
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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ProDOL: A general method to determine the degree of labelling for staining optimisation and molecular counting
Asenov Tashev, S., Euchner, J., Yserentant, K., Hapfelmeier, S., Hild, F., Chmielewicz, W., Hummert, J., Schwörer, F., Tsopoulidis, N., Germer, S., Saßmannshausen, Z., Fackler, O. T., Klingmüller, U. & Herten, D., 26 Mar 2024, (Accepted/In press) In: Nature Methods.Research output: Contribution to journal › Article › peer-review
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Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists
Clark, J. C., Martin, E. M., Morán, L. A., Di, Y., Wang, X., Zuidscherwoude, M., Brown, H. C., Kavanagh, D. M., Hummert, J., Eble, J. A., Nieswandt, B., Stegner, D., Pollitt, A. Y., Herten, D., Tomlinson, M. G., García, A. & Watson, S. P., 7 Apr 2023, In: Communications Biology. 6, 1, 17 p., 376.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
A dark intermediate in the fluorogenic reaction between tetrazine fluorophores and trans-cyclooctene
Hild, F., Werther, P., Yserentant, K., Wombacher, R. & Herten, D-P., 14 Dec 2022, In: Biophysical Reports. 2, 4, 8 p., 100084.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Downloads (Pure) -
Detecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching
Muzzopappa, F., Hummert, J., Anfossi, M., Tashev, S., Herten, D. & Erdel, F., 16 Dec 2022, In: Nature Communications. 13, 1, 15 p., 7787.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
Mandipropamid as a chemical inducer of proximity for in vivo applications
Ziegler, M. J., Yserentant, K., Dunsing, V., Middel, V., Gralak, A. J., Pakari, K., Bargstedt, J., Kern, C., Petrich, A., Chiantia, S., Strähle, U., Herten, D-P. & Wombacher, R., Jan 2022, In: Nature Chemical Biology. 18, 1, p. 64-69 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure)
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Unlocking the potential of single-photon wide-field microscopy
Engineering & Physical Science Research Council
1/04/24 → 31/03/27
Project: Research Councils
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Academy of Medical Sciences (AMS) Professorship for Dirk-Peter Herten
THE ACADEMY OF MEDICAL SCIENCES
1/08/20 → 30/09/24
Project: Research
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Super-resolved quantitative fluorescence imaging by quantum image scanning microscopy
The Weizmann Institute Of Science
1/07/20 → 28/02/23
Project: Research