Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

Ola Abdalsalam; Nicholas Ross; Guy A. Perkins; Robin Dale; Hamid Dehghani; Thomas D. O’Sullivan; Silvina L. Ferradal

doi:10.1117/12.2650970

Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

Ola Abdalsalam^*, Nicholas Ross, Guy A. Perkins, Robin Dale, Hamid Dehghani, Thomas D. O’Sullivan, Silvina L. Ferradal

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, non-ionizing imaging tool that can map brain hemodynamics. While not the most common fNIRS approach, frequency-domain NIRS (FD-NIRS) has shown an ability to estimate the absolute optical properties of tissues and, consequently, accurately estimate tissue chromophores concentrations. FD-NIRS can probe different depths in the tissue using multiple source-detector separations (multi-distance) or multiple modulation frequencies (multi-frequency). In this work, through experimental and simulation results, we demonstrate that using multi-distance and multi-frequency FD-NIRS yields similar results when estimating the optical properties of homogeneous and multi-layered tissues with less than ±10% error in estimations. We also examined some parameters that can affect the accuracy of the estimated optical properties, such as using different modulation frequencies in a multi-distance configuration and different source-detector separations for multi-frequency configuration.

Original language	English
Title of host publication	Optical Tomography and Spectroscopy of Tissue XV
Editors	Sergio Fantini, Paola Taroni
Publisher	SPIE
ISBN (Electronic)	9781510658578
DOIs	https://doi.org/10.1117/12.2650970
Publication status	Published - 7 Mar 2023
Event	Optical Tomography and Spectroscopy of Tissue XV 2023 - San Francisco, United States Duration: 30 Jan 2023 → 1 Feb 2023

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12376
ISSN (Print)	1605-7422

Conference

Conference	Optical Tomography and Spectroscopy of Tissue XV 2023
Country/Territory	United States
City	San Francisco
Period	30/01/23 → 1/02/23

Bibliographical note

Funding Information:
The research reported in this publication was supported by Indiana Clinical and Translational Science Institute (CTSI) award number (NIH-NCATS UL1TR002529). Additional support was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) Award Number R01EB029595. The content is solely the authors’ responsibility and does not necessarily represent the official views of the CTSI and the NIH.

Publisher Copyright:
© 2023 SPIE.

Keywords

diffuse optics
frequency domain
look-up-tables
multi-distance
multi-frequency
near infrared spectroscopy
slope method
two-layer model

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2650970Licence: None: All rights reserved

Cite this

Abdalsalam, O., Ross, N., Perkins, G. A., Dale, R., Dehghani, H., O’Sullivan, T. D., & Ferradal, S. L. (2023). Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy. In S. Fantini, & P. Taroni (Eds.), Optical Tomography and Spectroscopy of Tissue XV Article 1237607 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12376). SPIE. https://doi.org/10.1117/12.2650970

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abstract = "Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, non-ionizing imaging tool that can map brain hemodynamics. While not the most common fNIRS approach, frequency-domain NIRS (FD-NIRS) has shown an ability to estimate the absolute optical properties of tissues and, consequently, accurately estimate tissue chromophores concentrations. FD-NIRS can probe different depths in the tissue using multiple source-detector separations (multi-distance) or multiple modulation frequencies (multi-frequency). In this work, through experimental and simulation results, we demonstrate that using multi-distance and multi-frequency FD-NIRS yields similar results when estimating the optical properties of homogeneous and multi-layered tissues with less than ±10% error in estimations. We also examined some parameters that can affect the accuracy of the estimated optical properties, such as using different modulation frequencies in a multi-distance configuration and different source-detector separations for multi-frequency configuration.",

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author = "Ola Abdalsalam and Nicholas Ross and Perkins, {Guy A.} and Robin Dale and Hamid Dehghani and O{\textquoteright}Sullivan, {Thomas D.} and Ferradal, {Silvina L.}",

note = "Funding Information: The research reported in this publication was supported by Indiana Clinical and Translational Science Institute (CTSI) award number (NIH-NCATS UL1TR002529). Additional support was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) Award Number R01EB029595. The content is solely the authors{\textquoteright} responsibility and does not necessarily represent the official views of the CTSI and the NIH. Publisher Copyright: {\textcopyright} 2023 SPIE.; Optical Tomography and Spectroscopy of Tissue XV 2023 ; Conference date: 30-01-2023 Through 01-02-2023",

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Abdalsalam, O, Ross, N, Perkins, GA, Dale, R, Dehghani, H, O’Sullivan, TD & Ferradal, SL 2023, Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy. in S Fantini & P Taroni (eds), Optical Tomography and Spectroscopy of Tissue XV., 1237607, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12376, SPIE, Optical Tomography and Spectroscopy of Tissue XV 2023, San Francisco, United States, 30/01/23. https://doi.org/10.1117/12.2650970

Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy. / Abdalsalam, Ola; Ross, Nicholas; Perkins, Guy A. et al.
Optical Tomography and Spectroscopy of Tissue XV. ed. / Sergio Fantini; Paola Taroni. SPIE, 2023. 1237607 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12376).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

AU - Abdalsalam, Ola

AU - Ross, Nicholas

AU - Perkins, Guy A.

AU - Dale, Robin

AU - Dehghani, Hamid

AU - O’Sullivan, Thomas D.

AU - Ferradal, Silvina L.

N1 - Funding Information: The research reported in this publication was supported by Indiana Clinical and Translational Science Institute (CTSI) award number (NIH-NCATS UL1TR002529). Additional support was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) Award Number R01EB029595. The content is solely the authors’ responsibility and does not necessarily represent the official views of the CTSI and the NIH. Publisher Copyright: © 2023 SPIE.

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N2 - Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, non-ionizing imaging tool that can map brain hemodynamics. While not the most common fNIRS approach, frequency-domain NIRS (FD-NIRS) has shown an ability to estimate the absolute optical properties of tissues and, consequently, accurately estimate tissue chromophores concentrations. FD-NIRS can probe different depths in the tissue using multiple source-detector separations (multi-distance) or multiple modulation frequencies (multi-frequency). In this work, through experimental and simulation results, we demonstrate that using multi-distance and multi-frequency FD-NIRS yields similar results when estimating the optical properties of homogeneous and multi-layered tissues with less than ±10% error in estimations. We also examined some parameters that can affect the accuracy of the estimated optical properties, such as using different modulation frequencies in a multi-distance configuration and different source-detector separations for multi-frequency configuration.

AB - Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, non-ionizing imaging tool that can map brain hemodynamics. While not the most common fNIRS approach, frequency-domain NIRS (FD-NIRS) has shown an ability to estimate the absolute optical properties of tissues and, consequently, accurately estimate tissue chromophores concentrations. FD-NIRS can probe different depths in the tissue using multiple source-detector separations (multi-distance) or multiple modulation frequencies (multi-frequency). In this work, through experimental and simulation results, we demonstrate that using multi-distance and multi-frequency FD-NIRS yields similar results when estimating the optical properties of homogeneous and multi-layered tissues with less than ±10% error in estimations. We also examined some parameters that can affect the accuracy of the estimated optical properties, such as using different modulation frequencies in a multi-distance configuration and different source-detector separations for multi-frequency configuration.

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KW - multi-frequency

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KW - slope method

KW - two-layer model

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M3 - Conference contribution

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Abdalsalam O, Ross N, Perkins GA, Dale R, Dehghani H, O’Sullivan TD et al. Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy. In Fantini S, Taroni P, editors, Optical Tomography and Spectroscopy of Tissue XV. SPIE. 2023. 1237607. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2650970

Comparison of multi-distance and multi-frequency methods in frequency-domain near-infrared spectroscopy

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this