Abstract
A tomographic reconstruction algorithm for Cherenkov-excited luminescence scanned imaging (CELSI) is proposed and demonstrated for the first time, to reconstruct distributions of luminescent source. Coupled continuous wave (CW) diffusion equations are used to model luminescent photon propagation in biological tissues. The CELSI reconstruction was achieved by minimizing the difference between measured and computed data based on Tikhonov regularization technique. The feasibility and effectiveness of the algorithm were tested with numerical simulations on noisy data. In addition, comparisons between conventional diffuse optical fluorescence tomography (DOFT) and CELSI were also performed. Contrast-detail analysis was also used to evaluate the imaging performance of CELSI.
Original language | English |
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Title of host publication | Molecular-Guided Surgery |
Subtitle of host publication | Molecules, Devices, and Applications III |
Editors | Sylvain Gioux, Brian W. Pogue |
Publisher | SPIE |
ISBN (Electronic) | 9781510605398 |
DOIs | |
Publication status | Published - 2017 |
Event | Molecular-Guided Surgery: Molecules, Devices, and Applications III - San Francisco, United States Duration: 28 Jan 2017 → 30 Jan 2017 |
Publication series
Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Volume | 10049 |
ISSN (Print) | 1605-7422 |
Conference
Conference | Molecular-Guided Surgery: Molecules, Devices, and Applications III |
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Country/Territory | United States |
City | San Francisco |
Period | 28/01/17 → 30/01/17 |
Bibliographical note
Publisher Copyright:© 2017 SPIE.
Keywords
- Cherenkov-excited luminescence scanned imaging (CELSI)
- Image reconstruction
- Radiation therapy
- Tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging