Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study

Shao Yi He; Wei Sen Zhang; Chao Qiang Jiang; Ya Li Jin; Tai Hing Lam; Kar Keung Cheng; Lin Xu

doi:10.1038/s41598-024-54378-1

Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study

Shao Yi He, Wei Sen Zhang^*, Chao Qiang Jiang, Ya Li Jin, Tai Hing Lam, Kar Keung Cheng, Lin Xu^*

^*Corresponding author for this work

Applied Health Research

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Abstract

To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations of self-reported ACEs number with hemoglobin concentrations (g/dL) and presence of anemia. Older individuals with two or more ACEs, versus no ACEs, showed lower hemoglobin concentrations (β = − 0.08 g/dL, 95% confidence intervals (CI) − 0.12 to − 0.03) and higher odds of anemia (odds ratio = 1.26, 95% CI 1.01–1.59). A more pronounced association between ACEs and anemia in the lower education group was found, while the association became non-significant in those with higher education (P for ACEs-education interaction = 0.02). ACEs was associated with anemia in older people, and the association was stronger in those with lower education, highlighting the significance of early-life psychological stressors assessment and consideration of education background in geriatric care.

Original language	English
Article number	4729
Number of pages	10
Journal	Scientific Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-54378-1
Publication status	Published - 27 Feb 2024

Bibliographical note

Funding:
This work was supported by the Natural Science Foundation of China (No. 82373661). The Guangzhou Biobank Cohort Study was funded the University of Hong Kong Foundation for Educational Development and Research (SN/1f./HKUF-DC; C20400.28505200), the Health Medical Research Fund (Grant number: HMRF/13143241) in Hong Kong; the Guangzhou Public Health Bureau (201102A211004011) and the Guangzhou Science and Technology Bureau, Guangzhou, China (2002Z2-E2051; 2012J5100041; 2013J4100031; 201704030132); and the University of Birmingham, UK.

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title = "Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study",

abstract = "To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations of self-reported ACEs number with hemoglobin concentrations (g/dL) and presence of anemia. Older individuals with two or more ACEs, versus no ACEs, showed lower hemoglobin concentrations (β = − 0.08 g/dL, 95% confidence intervals (CI) − 0.12 to − 0.03) and higher odds of anemia (odds ratio = 1.26, 95% CI 1.01–1.59). A more pronounced association between ACEs and anemia in the lower education group was found, while the association became non-significant in those with higher education (P for ACEs-education interaction = 0.02). ACEs was associated with anemia in older people, and the association was stronger in those with lower education, highlighting the significance of early-life psychological stressors assessment and consideration of education background in geriatric care.",

author = "He, {Shao Yi} and Zhang, {Wei Sen} and Jiang, {Chao Qiang} and Jin, {Ya Li} and Lam, {Tai Hing} and Cheng, {Kar Keung} and Lin Xu",

note = "Funding: This work was supported by the Natural Science Foundation of China (No. 82373661). The Guangzhou Biobank Cohort Study was funded the University of Hong Kong Foundation for Educational Development and Research (SN/1f./HKUF-DC; C20400.28505200), the Health Medical Research Fund (Grant number: HMRF/13143241) in Hong Kong; the Guangzhou Public Health Bureau (201102A211004011) and the Guangzhou Science and Technology Bureau, Guangzhou, China (2002Z2-E2051; 2012J5100041; 2013J4100031; 201704030132); and the University of Birmingham, UK.",

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AU - Lam, Tai Hing

AU - Cheng, Kar Keung

AU - Xu, Lin

N1 - Funding: This work was supported by the Natural Science Foundation of China (No. 82373661). The Guangzhou Biobank Cohort Study was funded the University of Hong Kong Foundation for Educational Development and Research (SN/1f./HKUF-DC; C20400.28505200), the Health Medical Research Fund (Grant number: HMRF/13143241) in Hong Kong; the Guangzhou Public Health Bureau (201102A211004011) and the Guangzhou Science and Technology Bureau, Guangzhou, China (2002Z2-E2051; 2012J5100041; 2013J4100031; 201704030132); and the University of Birmingham, UK.

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N2 - To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations of self-reported ACEs number with hemoglobin concentrations (g/dL) and presence of anemia. Older individuals with two or more ACEs, versus no ACEs, showed lower hemoglobin concentrations (β = − 0.08 g/dL, 95% confidence intervals (CI) − 0.12 to − 0.03) and higher odds of anemia (odds ratio = 1.26, 95% CI 1.01–1.59). A more pronounced association between ACEs and anemia in the lower education group was found, while the association became non-significant in those with higher education (P for ACEs-education interaction = 0.02). ACEs was associated with anemia in older people, and the association was stronger in those with lower education, highlighting the significance of early-life psychological stressors assessment and consideration of education background in geriatric care.

AB - To examine the association of adverse childhood experiences (ACEs) with anemia among older people. 24,116 participants aged 50 years or above were recruited. Multivariable linear and logistic regression was used to assess the associations of self-reported ACEs number with hemoglobin concentrations (g/dL) and presence of anemia. Older individuals with two or more ACEs, versus no ACEs, showed lower hemoglobin concentrations (β = − 0.08 g/dL, 95% confidence intervals (CI) − 0.12 to − 0.03) and higher odds of anemia (odds ratio = 1.26, 95% CI 1.01–1.59). A more pronounced association between ACEs and anemia in the lower education group was found, while the association became non-significant in those with higher education (P for ACEs-education interaction = 0.02). ACEs was associated with anemia in older people, and the association was stronger in those with lower education, highlighting the significance of early-life psychological stressors assessment and consideration of education background in geriatric care.

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DO - 10.1038/s41598-024-54378-1

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JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 4729

ER -

Association of adverse childhood experiences with anemia in older Chinese: Guangzhou Biobank Cohort Study

Abstract

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